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    Gmpr2 guanosine monophosphate reductase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192357, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Gmpr2provided by RGD
    Official Full Name
    guanosine monophosphate reductase 2provided by RGD
    Primary source
    RGD:628875
    See related
    EnsemblRapid:ENSRNOG00000020216 AllianceGenome:RGD:628875
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GMP reductase activity. Predicted to be involved in GMP metabolic process. Predicted to be part of GMP reductase complex. Orthologous to human GMPR2 (guanosine monophosphate reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 123.7), Adrenal (RPKM 109.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmpr2 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33135455..33144923)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29165421..29175933)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34352857..34362074)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene transglutaminase 1 Neighboring gene Rab geranylgeranyltransferase subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. Patton GC, et al. Nat Chem Biol, 2011 Oct 30. PMID 22037469, Free PMC Article
    2. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. Zhang J, et al. J Cancer Res Clin Oncol, 2003 Feb. PMID 12669231
    3. Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators. Spector T, et al. J Biol Chem, 1979 Apr 10. PMID 218932
    4. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. Deng Y, et al. Int J Biochem Cell Biol, 2002 Sep. PMID 12009299
    5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108877

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GMP reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GMP reductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GMP reductase 2
    Names
    guanosine monophosphate reductase isolog
    NP_001013054.1
    NP_001400700.1
    NP_001400701.1
    XP_006251988.1
    XP_063130029.1
    XP_063130030.1
    XP_063130031.1
    XP_063130033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013036.1 → NP_001013054.1  GMP reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_001013054.1

      Status: VALIDATED

      Source sequence(s)
      BC089848
      UniProtKB/TrEMBL
      Q5FVP6
      Conserved Domains (1) summary
      cd00381
      Location:10 → 280
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

    2. NM_001413771.1 → NP_001400700.1  GMP reductase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KH36
      Related
      ENSRNOP00000070108.3, ENSRNOT00000084554.3

    3. NM_001413772.1 → NP_001400701.1  GMP reductase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      Related
      ENSRNOP00000060006.2, ENSRNOT00000067150.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33135455..33144923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273960.1 → XP_063130030.1  GMP reductase 2 isoform X1

      UniProtKB/TrEMBL
      A6KH36

    2. XM_006251926.5 → XP_006251988.1  GMP reductase 2 isoform X2

      Conserved Domains (1) summary
      cd00381
      Location:10 → 280
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

    3. XM_063273959.1 → XP_063130029.1  GMP reductase 2 isoform X1

      UniProtKB/TrEMBL
      A6KH36

    4. XM_063273961.1 → XP_063130031.1  GMP reductase 2 isoform X2

    5. XM_063273963.1 → XP_063130033.1  GMP reductase 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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