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    Cd163 CD163 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312701, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cd163provided by RGD
    Official Full Name
    CD163 moleculeprovided by RGD
    Primary source
    RGD:1310382
    See related
    EnsemblRapid:ENSRNOG00000010253 AllianceGenome:RGD:1310382
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ED2
    Summary
    Predicted to enable scaffold protein binding activity. Predicted to be involved in endocytosis. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Biomarker of uveitis. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 505.2), Liver (RPKM 139.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4q42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (158770751..158804146)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157085080..157118470)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (156752063..156785467)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486636 Neighboring gene complement C1s, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene RIKEN cDNA 1700013D24 gene Neighboring gene uncharacterized LOC134486637

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serum levels of soluble CD163 and soluble CD14 following antibiotic therapy of patients with acute brucellosis. Sun H, et al. J Infect Dev Ctries, 2019 Aug 31. PMID 32069255
    2. Iron trafficking in patients with Indian Post kala-azar dermal leishmaniasis. Dighal A, et al. PLoS Negl Trop Dis, 2020 Feb. PMID 32023254, Free PMC Article
    3. Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder. Underwood ML, et al. AIDS, 2020 Feb 1. PMID 31687981, Free PMC Article
    4. Soluble CD163-Associated Dietary Patterns and the Risk of Metabolic Syndrome. Hu TY, et al. Nutrients, 2019 Apr 25. PMID 31027316, Free PMC Article
    5. Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans(1). McElroy AK, et al. Emerg Infect Dis, 2019 Feb. PMID 30666927, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
      Title: Macrophage regulation of the "second brain": CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model.
    2. An increased number of CD163(+) chondrocytes with enhanced phagocytic activity were discovered within degraded joint cartilage, indicating a role in eliminating degraded tissues.
      Title: The identification of CD163 expressing phagocytic chondrocytes in joint cartilage and its novel scavenger role in cartilage degradation.
    3. Significant parenchymal CD163+ cell accumulation is observed two days post traumatic brain injury and continuously increased in the investigated survival time.
      Title: Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury.
    4. identify CD163 on macrophages as an adhesion receptor for erythroblasts in erythroblastic islands, and suggest a regulatory role for CD163 during erythropoiesis
      Title: The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.
    5. A broadly expressed macrophage scavenger receptor that may play a role in the activation of macrophages during hemolytic and/or inflammatory conditions.
      Title: The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor cysteine-rich type 1 protein M130
    Names
    CD163 antigen
    cluster of differentiation 163

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107887.1 → NP_001101357.1  scavenger receptor cysteine-rich type 1 protein M130 precursor

      See identical proteins and their annotated locations for NP_001101357.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6ILI0, D3Z9U2
      Related
      ENSRNOP00000104317.1, ENSRNOT00000152480.1
      Conserved Domains (2) summary
      smart00202
      Location:721 → 821
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:726 → 821
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      158770751..158804146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237352.5 → XP_006237414.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVY2, D3Z9U2
      Related
      ENSRNOP00000069665.2, ENSRNOT00000084588.3
      Conserved Domains (2) summary
      smart00202
      Location:721 → 821
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:726 → 821
      SRCR; Scavenger receptor cysteine-rich domain

    2. XM_017592650.3 → XP_017448139.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

      UniProtKB/TrEMBL
      D3Z9U2

    3. XM_017592651.3 → XP_017448140.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

      UniProtKB/TrEMBL
      D3Z9U2
      Related
      ENSRNOP00000058828.2, ENSRNOT00000068407.3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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