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    Eea1 early endosome antigen 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314764, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Eea1provided by RGD
    Official Full Name
    early endosome antigen 1provided by RGD
    Primary source
    RGD:1310167
    See related
    EnsemblRapid:ENSRNOG00000021681 AllianceGenome:RGD:1310167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Predicted to be involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in recycling endosome. Orthologous to human EEA1 (early endosome antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 206.5), Kidney (RPKM 161.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eea1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (32441281..32608808)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (30554686..30722186)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (37101415..37186534)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 1 Neighboring gene uncharacterized LOC102546992 Neighboring gene uncharacterized LOC100912143 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein L6, pseudogene 8 Neighboring gene pleckstrin homology and RhoGEF domain containing G7 Neighboring gene EWS RNA-binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. High Resolution Localization of Rab5, EEA1, and Nectin-3 to Tubulobulbar Complexes in the Rat Testis. Adams A, et al. Anat Rec (Hoboken), 2017 Jun. PMID 28176461
    2. Multivalent endosome targeting by homodimeric EEA1. Dumas JJ, et al. Mol Cell, 2001 Nov. PMID 11741531
    3. Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. Nazarewicz RR, et al. J Biol Chem, 2011 Jan 28. PMID 21097843, Free PMC Article
    4. Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. Wan J, et al. J Neurosci, 2008 Sep 3. PMID 18768694, Free PMC Article
    5. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. Mu FT, et al. J Biol Chem, 1995 Jun 2. PMID 7768953

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in testicular tubulobulbar complexes, associated with large vesicles that lack an association with endoplasmic reticulum
      Title: High Resolution Localization of Rab5, EEA1, and Nectin-3 to Tubulobulbar Complexes in the Rat Testis.
    2. PKC-alpha is a necessary regulator of EEA1-dependent Akt signaling in early endosomes.
      Title: Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission, postsynaptic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation by host of viral process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonal spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of serine-pyruvate aminotransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    early endosome antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427400.1 → NP_001414329.1  early endosome antigen 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZV67, A6IG51
      Related
      ENSRNOP00000083105.2, ENSRNOT00000117665.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      32441281..32608808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080107.2 → XP_038936035.1  early endosome antigen 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K051, F1LUA1
      Related
      ENSRNOP00000071305.2, ENSRNOT00000087297.3
      Conserved Domains (4) summary
      PRK02224
      Location:77 → 637
      PRK02224; DNA double-strand break repair Rad50 ATPase
      TIGR02168
      Location:363 → 1196
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:1343 → 1405
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
      NF033930
      Location:1071 → 1327
      pneumo_PspA; pneumococcal surface protein A

    2. XM_039080106.2 → XP_038936034.1  early endosome antigen 1 isoform X4

      UniProtKB/TrEMBL
      F1LUA1
      Conserved Domains (4) summary
      PRK02224
      Location:119 → 679
      PRK02224; DNA double-strand break repair Rad50 ATPase
      TIGR02168
      Location:405 → 1238
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15730
      Location:1385 → 1447
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
      NF033930
      Location:1113 → 1369
      pneumo_PspA; pneumococcal surface protein A

    3. XM_063263461.1 → XP_063119531.1  early endosome antigen 1 isoform X3

      Related
      ENSRNOP00000094814.2, ENSRNOT00000107821.2

    4. XM_039080104.2 → XP_038936032.2  early endosome antigen 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIN6
      Related
      ENSRNOP00000092690.2, ENSRNOT00000095444.2

    5. XM_063263460.1 → XP_063119530.1  early endosome antigen 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8E0
      Related
      ENSRNOP00000087995.2, ENSRNOT00000103157.2

    6. XM_063263462.1 → XP_063119532.1  early endosome antigen 1 isoform X6

    7. XM_063263463.1 → XP_063119533.1  early endosome antigen 1 isoform X7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108086.2: Suppressed sequence

      Description
      NM_001108086.2: This RefSeq was removed because the transcript is 5'' incomplete
    Nucleotide Protein Strain
    Heading Accession and Version

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