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    Plxna1 plexin A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362398, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Plxna1provided by RGD
    Official Full Name
    plexin A1provided by RGD
    Primary source
    RGD:1560871
    See related
    EnsemblRapid:ENSRNOG00000017003 AllianceGenome:RGD:1560871
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560871
    Summary
    Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 197.4), Adrenal (RPKM 91.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (123295165..123340132, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (121737934..121782901, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (121217658..121262697, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102339 Neighboring gene uncharacterized LOC120102340 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of plexin-A subfamily members in the mouse nervous system. Murakami Y, et al. Dev Dyn, 2001 Mar. PMID 11241833
    2. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2. Toyofuku T, et al. Genes Dev, 2004 Feb 15. PMID 14977921, Free PMC Article
    3. Semaphorin signaling facilitates cleft formation in the developing salivary gland. Chung L, et al. Development, 2007 Aug. PMID 17626059
    4. Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Matsuoka RL, et al. Neuron, 2011 Aug 11. PMID 21835343, Free PMC Article
    5. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Gitler AD, et al. Dev Cell, 2004 Jul. PMID 15239958

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in olfactory nerve formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plexin-A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      123295165..123340132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002729398.6 → XP_002729444.2  plexin-A1

      See identical proteins and their annotated locations for XP_002729444.2

      UniProtKB/TrEMBL
      A0A8I6AGW9, A6IB60, D3Z981
      Related
      ENSRNOP00000099946.1, ENSRNOT00000137358.1
      Conserved Domains (7) summary
      cd11271
      Location:54 → 529
      Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
      cd01179
      Location:977 → 1062
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:880 → 976
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:1064 → 1164
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:530 → 572
      PSI; Plexin repeat
      pfam01833
      Location:1166 → 1250
      TIG; IPT/TIG domain
      pfam08337
      Location:1334 → 1882
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    Nucleotide Protein Strain
    Heading Accession and Version

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