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    Porcn porcupine O-acyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317368, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Porcnprovided by RGD
    Official Full Name
    porcupine O-acyltransferaseprovided by RGD
    Primary source
    RGD:1564947
    See related
    EnsemblRapid:ENSRNOG00000004819 AllianceGenome:RGD:1564947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564947
    Summary
    Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Predicted to be involved in several processes, including Wnt protein secretion; protein lipidation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to act upstream of or within glycoprotein metabolic process. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum; glutamatergic synapse; and membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 86.4), Lung (RPKM 36.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Porcn in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (16957811..16970440)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14285864..14298481)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15035569..15048440)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene FtsJ RNA 2'-O-methyltransferase 1 Neighboring gene uncharacterized LOC134484175 Neighboring gene EBP, cholestenol delta-isomerase Neighboring gene TBC1 domain family, member 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Wntless in Wnt secretion: molecular, cellular and genetic aspects. Das S, et al. Front Biol (Beijing), 2012 Dec 1. PMID 23439944, Free PMC Article
    2. Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Takada R, et al. Dev Cell, 2006 Dec. PMID 17141155
    3. Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission. Erlenhardt N, et al. Cell Rep, 2016 Feb 2. PMID 26776514, Free PMC Article
    4. Identification of key residues and regions important for porcupine-mediated Wnt acylation. Rios-Esteves J, et al. J Biol Chem, 2014 Jun 13. PMID 24798332, Free PMC Article
    5. The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. Kurimoto A, et al. J Biol Chem, 2014 Apr 25. PMID 24619415, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables palmitoleoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoleoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within glycoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein-serine O-palmitoleoyltransferase porcupine
    Names
    porcupine homolog
    protein-cysteine N-palmitoyltransferase porcupine
    NP_001166826.1
    XP_006256778.1
    XP_006256779.1
    XP_017457551.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173355.1 → NP_001166826.1  protein-serine O-palmitoleoyltransferase porcupine

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I5Y6B0
      Related
      ENSRNOP00000076744.1, ENSRNOT00000106543.2
      Conserved Domains (1) summary
      cl00738
      Location:31 → 343
      MBOAT; membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      16957811..16970440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256716.5 → XP_006256778.1  protein-serine O-palmitoleoyltransferase porcupine isoform X1

      See identical proteins and their annotated locations for XP_006256778.1

      UniProtKB/TrEMBL
      A0A8I6A8A2, A6KP40
      Related
      ENSRNOP00000087944.1, ENSRNOT00000118296.2
      Conserved Domains (1) summary
      cl00738
      Location:31 → 338
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    2. XM_006256717.5 → XP_006256779.1  protein-serine O-palmitoleoyltransferase porcupine isoform X2

      UniProtKB/TrEMBL
      A0A8I6APS0
      Related
      ENSRNOP00000095116.1, ENSRNOT00000103450.2
      Conserved Domains (1) summary
      cl00738
      Location:31 → 337
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    3. XM_017602062.3 → XP_017457551.1  protein-serine O-palmitoleoyltransferase porcupine isoform X3

      UniProtKB/TrEMBL
      D3ZVQ3
      Related
      ENSRNOP00000006491.7, ENSRNOT00000006491.9
    Nucleotide Protein Strain
    Heading Accession and Version

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