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    ORC3 origin recognition complex subunit 3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850656, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ORC3
    Gene description
    origin recognition complex subunit 3
    Primary source
    FungiDB:YLL004W
    Locus tag
    YLL004W
    See related
    SGD:S000003927; AllianceGenome:SGD:S000003927; VEuPathDB:YLL004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA replication origin binding activity and chromatin binding activity. Involved in DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and silent mating-type cassette heterochromatin assembly. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ORC3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (141073..142923)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ERMES complex subunit MMM1 Neighboring gene Spo75p Neighboring gene Sfi1p Neighboring gene H3 histone acetyltransferase RTT109

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast. Cheng X, et al. J Biol Chem, 2010 Sep 24. PMID 20659900, Free PMC Article
    2. Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Huang D, et al. Genes Dev, 2003 Jul 15. PMID 12865298, Free PMC Article
    3. Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Knott SR, et al. Cell, 2012 Jan 20. PMID 22265405, Free PMC Article
    4. Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Chen S, et al. Genes Dev, 2007 Nov 15. PMID 18006685, Free PMC Article
    5. The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Bose ME, et al. Mol Cell Biol, 2004 Jan. PMID 14701749, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear origin of replication recognition complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear origin of replication recognition complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of nuclear pre-replicative complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pre-replicative complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 3
    NP_013097.1
    • Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      141073..142923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181824.1 → NP_013097.1  TPA: origin recognition complex subunit 3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXZ9, P54790
      UniProtKB/TrEMBL
      A0A8H4BWV6, A7A0Q2, B3LTG2, B5VMT8, C7GPG1, C8ZCW9, N1P0C3
      Conserved Domains (1) summary
      cd20704
      Location:57 → 613
      Orc3; Origin recognition complex subunit 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54790.1

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