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    MNN4 Mnn4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853634, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MNN4
    Official Full Name
    Mnn4p
    Primary source
    SGD:S000001684
    Locus tag
    YKL201C
    See related
    AllianceGenome:SGD:S000001684; FungiDB:YKL201C; VEuPathDB:YKL201C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKL200C
    Summary
    Enables enzyme activator activity. Involved in protein N-linked glycosylation and protein O-linked glycosylation. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy (multiple) and muscular dystrophy (multiple). Orthologous to human FKTN (fukutin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MNN4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (63930..67466, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Eap1p Neighboring gene phosphatidylinositol kinase-related protein kinase TOR2 Neighboring gene putative serine/threonine protein kinase PTK1 Neighboring gene AAA family ATPase peroxin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of outer region mannosylphosphorylation on N-glycan formation by Candida albicans: normal acid-stable N-glycan formation requires acid-labile mannosylphosphate addition. Hazen KC, et al. Glycobiology, 2007 Oct. PMID 17670843
    2. Cloning and analysis of the MNN4 gene required for phosphorylation of N-linked oligosaccharides in Saccharomyces cerevisiae. Odani T, et al. Glycobiology, 1996 Dec. PMID 9023541
    3. Analysis of linkage positions in Saccharomyces cerevisiae D-mannans by the reductive-cleavage method. Bowie JU, et al. Carbohydr Res, 1984 Feb 15. PMID 6367979
    4. Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes. Kim YH, et al. Appl Microbiol Biotechnol, 2017 Apr. PMID 28101612
    5. Mannosylphosphate transfer to cell wall mannan is regulated by the transcriptional level of the MNN4 gene in Saccharomyces cerevisiae. Odani T, et al. FEBS Lett, 1997 Dec 29. PMID 9459307

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ybl006c (Rsc14) controls expression of MNN6, MNN4 and MNN1
      Title: Rsc14-controlled expression of MNN6, MNN4 and MNN1 regulates mannosylphosphorylation of Saccharomyces cerevisiae cell wall mannoproteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mnn4p
    NP_012721.1
    • Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; may also function as a mannosylphosphate transferase; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      63930..67466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179766.1 → NP_012721.1  TPA: Mnn4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX01, P36043, P36044, P89095
      UniProtKB/TrEMBL
      B5VLW5
      Conserved Domains (1) summary
      pfam04991
      Location:490 → 746
      LicD; LicD family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36044.2

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