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    EMC3 Emc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853628, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EMC3
    Official Full Name
    Emc3p
    Primary source
    SGD:S000001690
    Locus tag
    YKL207W
    See related
    AllianceGenome:SGD:S000001690; FungiDB:YKL207W; VEuPathDB:YKL207W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM27
    Summary
    Involved in protein folding in endoplasmic reticulum. Part of EMC complex. Orthologous to human EMC3 (ER membrane protein complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EMC3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (48194..48955)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Cbt1p Neighboring gene Add66p Neighboring gene Ran GTPase-binding protein LOS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
    2. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    3. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
    4. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article
    5. Secretory pathway genes assessed by high-throughput microscopy and synthetic genetic array analysis. Bircham PW, et al. Mol Biosyst, 2011 Sep. PMID 21731954

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emc3p
    NP_012715.3
    • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      48194..48955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179772.1 → NP_012715.3  TPA: Emc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012715.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A082, D6VWZ6, P36039, Q86ZT1
      UniProtKB/TrEMBL
      G2WHI7
      Conserved Domains (1) summary
      pfam01956
      Location:2 → 194
      DUF106; Integral membrane protein DUF106
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36039.3

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