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    MNN14 Mnn14p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853524, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MNN14
    Official Full Name
    Mnn14p
    Primary source
    SGD:S000003822
    Locus tag
    YJR061W
    See related
    AllianceGenome:SGD:S000003822; FungiDB:YJR061W; VEuPathDB:YJR061W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in N-glycan processing. Human ortholog(s) of this gene implicated in dilated cardiomyopathy (multiple) and muscular dystrophy (multiple). Orthologous to human FKTN (fukutin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MNN14 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (550511..553318)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein kinase PTK2 Neighboring gene Cbf1p Neighboring gene amidase Neighboring gene DNA-directed RNA polymerase I core subunit RPA12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Abolishment of N-glycan mannosylphosphorylation in glyco-engineered Saccharomyces cerevisiae by double disruption of MNN4 and MNN14 genes. Kim YH, et al. Appl Microbiol Biotechnol, 2017 Apr. PMID 28101612
    2. The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae. Lamb TM, et al. Mol Cell Biol, 2003 Jan. PMID 12509465, Free PMC Article
    3. Screening for new yeast mutants affected in mannosylphosphorylation of cell wall mannoproteins. Conde R, et al. Yeast, 2003 Oct 30. PMID 14587103
    4. Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Jensen TH, et al. Mol Cell Biol, 2000 Nov. PMID 11027275, Free PMC Article
    5. Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors. Albers M, et al. RNA, 2003 Jan. PMID 12554883, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Mnn14p
    NP_012595.1
    • Protein required for N-glycan mannosylphosphorylation; non-essential gene; transcription repressed by Rm101p; MNN14 has a paralog, MNN4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      550511..553318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181719.1 → NP_012595.1  TPA: Mnn14p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWN2, P40355
      UniProtKB/TrEMBL
      C8ZBK9, N1P041
      Conserved Domains (1) summary
      pfam04991
      Location:470 → 720
      LicD; LicD family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40355.2

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