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    APS2 Aps2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853521, updated on 17-May-2024

    Summary

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    Gene symbol
    APS2
    Gene description
    Aps2p
    Primary source
    FungiDB:YJR058C
    Locus tag
    YJR058C
    See related
    SGD:S000003819; AllianceGenome:SGD:S000003819; VEuPathDB:YJR058C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YAP17
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Located in clathrin-coated vesicle. Part of AP-2 adaptor complex. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APS2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (544732..545175, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene bifunctional thymidylate/uridylate kinase Neighboring gene protein kinase PTK2 Neighboring gene Cbf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins. Nakai M, et al. Biochim Biophys Acta, 1993 Sep 23. PMID 8373805
    2. The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. Phan HL, et al. EMBO J, 1994 Apr 1. PMID 8157009, Free PMC Article
    3. Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses. Chapa-y-Lazo B, et al. Traffic, 2014 May. PMID 24460703, Free PMC Article
    4. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339
    5. AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. Kirchhausen T, et al. J Biol Chem, 1991 Jun 15. PMID 2040623

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of AP-2 adaptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    Aps2p
    NP_012592.1
    • Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      544732..545175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181716.1 → NP_012592.1  TPA: Aps2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWM9, Q00381
      UniProtKB/TrEMBL
      A0A6A5PXF5, A6ZQ17, B3LQE7, C7GME5, C8ZBK7, G2WH63, N1P8Q4
      Conserved Domains (1) summary
      cl38905
      Location:3 → 146
      longin-like; Longin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00381.1

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