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    EGH1 hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854824, updated on 29-Jun-2024

    Summary

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    Gene symbol
    EGH1
    Gene description
    hydrolase
    Primary source
    FungiDB:YIR007W
    Locus tag
    YIR007W
    See related
    SGD:S000001446; AllianceGenome:SGD:S000001446; VEuPathDB:YIR007W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables steryl-beta-glucosidase activity. Involved in ergosteryl 3-beta-D-glucoside catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See EGH1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (370704..372998)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Pan1p Neighboring gene tRNA-Glu Neighboring gene DNA primase subunit PRI1 Neighboring gene U2 snRNP complex subunit MSL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae. Watanabe T, et al. Glycobiology, 2015 Oct. PMID 26116408
    2. Identification of a Saccharomyces cerevisiae glucosidase that hydrolyzes flavonoid glucosides. Schmidt S, et al. Appl Environ Microbiol, 2011 Mar. PMID 21216897, Free PMC Article
    3. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
    4. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article
    5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Egh1 is an ergosteryl-beta-glucosidase that is functionally involved in the ergosteryl-beta-glucoside catabolic pathway and vacuole formation in S. cerevisiae.
      Title: Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steryl-beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steryl-beta-glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate derivative catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ergosteryl 3-beta-D-glucoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosteryl 3-beta-D-glucoside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydrolase
    NP_012272.3
    • Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      370704..372998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179529.3 → NP_012272.3  TPA: hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012272.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVT7, P40566
      UniProtKB/TrEMBL
      A0A8H4BZF9, A6ZVS6, N1P2A5
      Conserved Domains (2) summary
      pfam18564
      Location:654 → 738
      Glyco_hydro_5_C; Glycoside hydrolase family 5 C-terminal domain
      cl23725
      Location:77 → 133
      Glyco_hydro; Glycosyl hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40566.1

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