CTR2 low-affinity Cu transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CTR2
Official Full Name: low-affinity Cu transporter
Primary source: SGD:S000001218
Locus tag: YHR175W
See related: AllianceGenome:SGD:S000001218; FungiDB:YHR175W; VEuPathDB:YHR175W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables copper ion transmembrane transporter activity. Involved in cellular copper ion homeostasis; copper ion import; and protein maturation by copper ion transfer. Located in fungal-type vacuole membrane. Orthologous to several human genes including SLC31A1 (solute carrier family 31 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CTR2 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (452872..453441)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription of CTR2 driven by the GPD promoter, which is not identical to the CTR2 promoter, affects degradation of the transcripts by nonsense-mediated mRNA decay pathway.
Title: Regulation of CTR2 mRNA by the nonsense-mediated mRNA decay pathway.
CTR2 plays a role in regulating the level of copper in the cytoplasm. Copper tolerance by the upf1Delta mutant is dependent on the presence of CTR2.
Title: Physiological basis of copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants.
These data suggest that Aft1p and Mac1p might corporately regulate transcription of CTR2.
Title: Metal-sensing transcription factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces cerevisiae.
these results suggest that Mac1p can activate the expression of vacuolar copper transporter Ctr2p in response to copper deficiency, resulting in yeast resistance to copper starvation.
Title: Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces cerevisiae.
Ctr2-1, a mutant form of Ctr2 that mislocalizes to the plasma membrane, requires the Fre1 plasma membrane metalloreductase for Cu(I) import.
Title: Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization.
demonstrate that copper transporter Ctr2 mobilizes vacuolar copper stores in a manner dependent on conserved amino acid residues
Title: Mobilization of intracellular copper stores by the ctr2 vacuolar copper transporter.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables copper ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables copper ion transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables copper ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in copper ion import	IGI Inferred from Genetic Interaction more info	PubMed
involved_in copper ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by copper ion transfer	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: low-affinity Cu transporter

NP_012045.3

Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

452872..453441

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179306.3 → NP_012045.3 TPA: low-affinity Cu transporter [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012045.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLC3, P38865

UniProtKB/TrEMBL

B3LST7, B5VKA2, C7GW85, C8Z9X1, N1P9H7

Conserved Domains (1) summary

pfam04145
Location:61 → 166

Ctr; Ctr copper transporter family