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    CWC23 U2-type spliceosomal complex subunit CWC23 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852749, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CWC23
    Official Full Name
    U2-type spliceosomal complex subunit CWC23
    Primary source
    SGD:S000003096
    Locus tag
    YGL128C
    See related
    AllianceGenome:SGD:S000003096; FungiDB:YGL128C; VEuPathDB:YGL128C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in spliceosomal complex disassembly. Part of U2-type spliceosomal complex. Orthologous to human DNAJC17 (DnaJ heat shock protein family (Hsp40) member C17). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CWC23 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (269293..270144, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mRNA guanylyltransferase Neighboring gene mitochondrial 37S ribosomal protein RSM23 Neighboring gene mediator complex subunit SOH1 Neighboring gene Scs3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cwc23 is a component of the NTR complex and functions to stabilize Ntr1 and facilitate disassembly of spliceosome intermediates. Su YL, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29390077, Free PMC Article
    2. Co-evolution of spliceosomal disassembly interologs: crowning J-protein component with moonlighting RNA-binding activity. Raut S, et al. Curr Genet, 2019 Apr. PMID 30467716
    3. Disruption of six novel Saccharomyces cerevisiae genes reveals that YGL129c is necessary for growth in non-fermentable carbon sources, YGL128c for growth at low or high temperatures and YGL125w is implicated in the biosynthesis of methionine. Tizón B, et al. Yeast, 1999 Jan 30. PMID 10029993
    4. Cwc23, an essential J protein critical for pre-mRNA splicing with a dispensable J domain. Sahi C, et al. Mol Cell Biol, 2010 Jan. PMID 19822657, Free PMC Article
    5. Network of general and specialty J protein chaperones of the yeast cytosol. Sahi C, et al. Proc Natl Acad Sci U S A, 2007 Apr 24. PMID 17438278, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex disassembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2-type spliceosomal complex subunit CWC23
    NP_011387.2
    • Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      269293..270144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180993.1 → NP_011387.2  TPA: U2-type spliceosomal complex subunit CWC23 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011387.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU20, P52868, Q6B1S2
      UniProtKB/TrEMBL
      B3LHI8, C7GX63, C8Z8C2, G2WDX4, N1P1Q0
      Conserved Domains (2) summary
      COG2214
      Location:14 → 228
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:15 → 84
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52868.2

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