CDC14 phosphoprotein phosphatase CDC14 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC14
Gene description: phosphoprotein phosphatase CDC14
Primary source: FungiDB:YFR028C
Locus tag: YFR028C
See related: SGD:S000001924; AllianceGenome:SGD:S000001924; VEuPathDB:YFR028C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OAF3
Summary: Enables protein serine/threonine phosphatase activity. Involved in several processes, including organelle disassembly; peptidyl-serine dephosphorylation; and positive regulation of organelle organization. Located in cytoplasm; nucleolus; and spindle pole body. Part of RENT complex. Used to study autosomal recessive nonsyndromic deafness 32; colorectal carcinoma; and vascular disease. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to several human genes including CDC14A (cell division cycle 14A) and CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CDC14 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (208413..210068, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Saccharomyces cerevisiae deficient in the early anaphase release of Cdc14 can traverse anaphase I without ribosomal DNA disjunction and successfully complete meiosis.
Title: Saccharomyces cerevisiae deficient in the early anaphase release of Cdc14 can traverse anaphase I without ribosomal DNA disjunction and successfully complete meiosis.
Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
Title: Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
Title: Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
Title: Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
Title: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
Cross-compartment signal propagation in the mitotic exit network.
Title: Cross-compartment signal propagation in the mitotic exit network.
Cdc14 protein phosphatase and topoisomerase II mediate rDNA dynamics and nucleophagic degradation of nucleolar proteins after TORC1 inactivation.
Title: Cdc14 protein phosphatase and topoisomerase II mediate rDNA dynamics and nucleophagic degradation of nucleolar proteins after TORC1 inactivation.
The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.
Title: The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.
Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
Title: Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
Cdc14 plays very specific, and often different, roles in counteracting Cdk phosphorylation in all species.
Title: Re-examining the role of Cdc14 phosphatase in reversal of Cdk phosphorylation during mitotic exit.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
involved_in meiotic spindle disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic actomyosin contractile ring assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA chromatin condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RENT complex	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular non-membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in new mitotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole body	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoprotein phosphatase CDC14

NP_116684.3

EC 3.1.3.48

Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

208413..210068 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179993.3 → NP_116684.3 TPA: phosphoprotein phosphatase CDC14 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116684.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTQ8, Q00684, Q05180, Q05673

UniProtKB/TrEMBL

A0A6A5Q1R2, A7A265, C7GYD2, C8Z7W3, G2WDG6, N1P4Q7

Conserved Domains (3) summary

PRK08581
Location:403 → 513

PRK08581; amidase domain-containing protein

cd14499
Location:161 → 340

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

pfam14671
Location:14 → 151

DSPn; Dual specificity protein phosphatase, N-terminal half