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    FIR1 Fir1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856754, updated on 17-May-2024

    Summary

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    Gene symbol
    FIR1
    Gene description
    Fir1p
    Primary source
    FungiDB:YER032W
    Locus tag
    YER032W
    See related
    SGD:S000000834; AllianceGenome:SGD:S000000834; VEuPathDB:YER032W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PIP1
    Summary
    Involved in mRNA polyadenylation and regulation of cytokinesis. Located in cellular bud neck. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FIR1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (215063..217693)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Chz1p Neighboring gene Rab family GTPase YPT31 Neighboring gene Zrg8p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p. Hershkovits G, et al. Proc Natl Acad Sci U S A, 2006 Jun 27. PMID 16788068, Free PMC Article
    2. RNA binding analysis of yeast REF2 and its two-hybrid interaction with a new gene product, FIR1. Russnak R, et al. Gene Expr, 1996. PMID 9196079, Free PMC Article
    3. A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks. Zhang K, et al. Nucleic Acids Res, 2016 Jun 20. PMID 26908650, Free PMC Article
    4. Identification of factors regulating poly(A) tail synthesis and maturation. Mangus DA, et al. Mol Cell Biol, 2004 May. PMID 15121841, Free PMC Article
    5. Broader roles of the ubiquitin-like protein Hub1 indicated by its yeast two-hybrid interactors. Varikkapulakkal A, et al. MicroPubl Biol, 2022. PMID 35098049, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fir1p
    NP_010949.4
    • Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      215063..217693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178923.3 → NP_010949.4  TPA: Fir1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010949.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLT1, P40020
      UniProtKB/TrEMBL
      A0A8H8ULP4, C7GSH9, C8Z734
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40020.3

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