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    VPS64 Vps64p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851781, updated on 29-Jun-2024

    Summary

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    Gene symbol
    VPS64
    Gene description
    Vps64p
    Primary source
    FungiDB:YDR200C
    Locus tag
    YDR200C
    See related
    SGD:S000002608; AllianceGenome:SGD:S000002608; VEuPathDB:YDR200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FAR9
    Summary
    Involved in TOR signaling and re-entry into mitotic cell cycle after pheromone arrest. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VPS64 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (854279..856093, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cbs2p Neighboring gene protein-lysine N-methyltransferase Neighboring gene Spc19p Neighboring gene Rav2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. Lai F, et al. FEMS Yeast Res, 2011 Feb. PMID 20977626
    2. Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum. Pracheil T, et al. J Biol Chem, 2013 Jun 7. PMID 23625923, Free PMC Article
    3. Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy. Innokentev A, et al. Elife, 2020 Dec 15. PMID 33317697, Free PMC Article
    4. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article
    5. The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. Huang M, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760057

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in re-entry into mitotic cell cycle after pheromone arrest IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps64p
    NP_010486.3
    • Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog, FAR10, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      854279..856093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180508.3 → NP_010486.3  TPA: Vps64p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010486.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSI2, Q03944
      UniProtKB/TrEMBL
      A0A8H8UNA8, A6ZYF8, B3LG84, B5VG92, N1P8D8
      Conserved Domains (2) summary
      COG1716
      Location:126 → 304
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      TIGR02168
      Location:406 → 580
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03944.1

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