PTC6 type 2C protein phosphatase PTC6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PTC6
Gene description: type 2C protein phosphatase PTC6
Primary source: FungiDB:YCR079W
Locus tag: YCR079W
See related: SGD:S000002133; AllianceGenome:SGD:S000002133; VEuPathDB:YCR079W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AUP1; PPP2
Summary: Enables [pyruvate dehydrogenase (lipoamide)] phosphatase activity and protein serine/threonine phosphatase activity. Involved in several processes, including autophagy of mitochondrion; peptidyl-serine dephosphorylation; and positive regulation of pyruvate dehydrogenase activity. Located in mitochondrial intermembrane space and mitochondrial matrix. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PTC6 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (252845..254173)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Ptc6p is the primary pyruvate dehydrogenase phosphatase in S. cerevisiae; Ptc6p exhibits substrate specificity for additional phosphatases.
Title: Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase.
S. cerevisiae PTC6 participates in the negative regulation of Slt2 phosphorylation and vacuole morphogenesis under cell wall stress conditions
Title: Type 2C protein phosphatase Ptc6 participates in activation of the Slt2-mediated cell wall integrity pathway in Saccharomyces cerevisiae.
the function of Aup1 in mitophagy could be explained through its regulation of Rtg3-dependent transcription.
Title: Aup1-mediated regulation of Rtg3 during mitophagy.
Pkp2p (Ygl059wp) and Ppp2p (Ycr079wp), are engaged in the regulation of this complex by affecting the phosphorylation state of Pda1p.
Title: Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases.
encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae and confers rapamycin-resistant function.
Title: The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: type 2C protein phosphatase PTC6

NP_010003.2

EC 3.1.3.16

EC 3.1.3.43

Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

252845..254173

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180034.1 → NP_010003.2 TPA: type 2C protein phosphatase PTC6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010003.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR81, P25646, Q8NIL5

UniProtKB/TrEMBL

A6ZTQ2, C7GUW8, G2WA88, N1PAN4

Conserved Domains (1) summary

pfam00481
Location:108 → 401

PP2C; Protein phosphatase 2C