SAT4 serine/threonine protein kinase SAT4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: SAT4
Gene description: serine/threonine protein kinase SAT4
Primary source: FungiDB:YCR008W
Locus tag: YCR008W
See related: SGD:S000000601; AllianceGenome:SGD:S000000601; VEuPathDB:YCR008W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HAL4
Summary: Enables protein kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; cellular protein modification process; and detection of nutrient. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Authors demonstrate that loss of Hal4 and Hal5 activates endocytosis of many different kinds of PM proteins, including Art1-mediated and Art1-independent endocytic events.
Title: A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast.
Caffeine sensitivity of the Deltappz1 disruptant is suppressed by disruption of either SAT4 or HAL5.
Title: Saccharomyces cerevisiae protein phosphatase Ppz1 and protein kinases Sat4 and Hal5 are involved in the control of subcellular localization of Gln3 by likely regulating its phosphorylation state.
Hal4 and Hal5 are required for control of carbon and nitrogen uptake and metabolism.
Title: Hal4 and Hal5 protein kinases are required for general control of carbon and nitrogen uptake and metabolism.
Sat4/Hal4 and Hal5 stabilize the transporter at the plasma membrane under low K+ conditions, preventing its endocytosis and vacuolar degradation.
Title: Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular monoatomic cation homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein lipoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

NP_009934.1

Ser/Thr protein kinase involved in salt tolerance, nutrient response; functions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion

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The following sections contain reference sequences that belong to a specific genome build. Explain