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    ATG22 Atg22p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850319, updated on 1-Aug-2024

    Summary

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    Gene symbol
    ATG22
    Gene description
    Atg22p
    Primary source
    FungiDB:YCL038C
    Locus tag
    YCL038C
    See related
    SGD:S000000543; AllianceGenome:SGD:S000000543; VEuPathDB:YCL038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AUT4
    Summary
    Involved in amino acid transmembrane export from vacuole. Is integral component of fungal-type vacuolar membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATG22 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (54941..56527, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene glucokinase Neighboring gene glucose-induced degradation complex subunit GID7 Neighboring gene Sro9p Neighboring gene Gfd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of Atg22 gene contributes to reduce programmed cell death induced by acetic acid stress in Saccharomyces cerevisiae. Hu J, et al. Biotechnol Biofuels, 2019. PMID 31890026, Free PMC Article
    2. Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Yang Z, et al. Mol Biol Cell, 2006 Dec. PMID 17021250, Free PMC Article
    3. The breakdown of autophagic vesicles inside the vacuole depends on Aut4p. Suriapranata I, et al. J Cell Sci, 2000 Nov. PMID 11058089
    4. Autophagy as a Mechanism for Adaptive Prediction-Mediated Emergence of Drug Resistance. Nivedita N, et al. Front Microbiol, 2021. PMID 34566920, Free PMC Article
    5. Autophagy is required for G₁/G₀ quiescence in response to nitrogen starvation in Saccharomyces cerevisiae. An Z, et al. Autophagy, 2014 Oct 1. PMID 25126732, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane export from vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane export from vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg22p
    NP_009892.1
    • Vacuolar membrane protein; required for efflux of amino acids during autophagic body breakdown in vacuole; targeted to vacuole via AP-3 pathway; null mutation causes gradual loss of viability during starvation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      54941..56527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178683.1 → NP_009892.1  TPA: Atg22p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTF2, D6VQX7, P25568
      UniProtKB/TrEMBL
      N1P7Z2
      Conserved Domains (1) summary
      cd17483
      Location:28 → 484
      MFS_Atg22_like; Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25568.1

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