U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PYC2 pyruvate carboxylase 2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852519, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    PYC2
    Gene description
    pyruvate carboxylase 2
    Primary source
    FungiDB:YBR218C
    Locus tag
    YBR218C
    See related
    SGD:S000000422; AllianceGenome:SGD:S000000422; VEuPathDB:YBR218C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyruvate carboxylase activity. Involved in gluconeogenesis. Located in cytosol. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PYC2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (658707..662249, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ybp1p Neighboring gene Atg12p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulation of pyc1 encoding pyruvate carboxylase isozyme I by nitrogen sources in Saccharomyces cerevisiae. Huet C, et al. Eur J Biochem, 2000 Dec. PMID 11082192
    2. Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA. Jitrapakdee S, et al. Int J Biochem Cell Biol, 2007. PMID 17478118, Free PMC Article
    3. Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype. Flores CL, et al. Eukaryot Cell, 2005 Feb. PMID 15701798, Free PMC Article
    4. Phosphopyruvate carboxylase from baker's yeast. I. Isolation, purification, and characterization. CANNATA JJ, et al. J Biol Chem, 1963 Apr. PMID 14018315
    5. By-product formation during exposure of respiring Saccharomyces cerevisiae cultures to excess glucose is not caused by a limited capacity of pyruvate carboxylase. Bauer J, et al. FEMS Microbiol Lett, 1999 Oct 1. PMID 10481094

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    pyruvate carboxylase 2
    NP_009777.1
    • Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      658707..662249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178566.1 → NP_009777.1  TPA: pyruvate carboxylase 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQL4, P32327
      UniProtKB/TrEMBL
      A0A8H4BVC4, A6ZLF8, B3LMU2, G2W9M1
      Conserved Domains (1) summary
      COG1038
      Location:15 → 1171
      PycA; Pyruvate carboxylase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32327.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools