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    ADH5 alcohol dehydrogenase ADH5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852442, updated on 9-Jun-2024

    Summary

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    Gene symbol
    ADH5
    Gene description
    alcohol dehydrogenase ADH5
    Primary source
    FungiDB:YBR145W
    Locus tag
    YBR145W
    See related
    SGD:S000000349; AllianceGenome:SGD:S000000349; VEuPathDB:YBR145W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable alcohol dehydrogenase (NAD+) activity. Involved in NADH oxidation; amino acid catabolic process to alcohol via Ehrlich pathway; and ethanol biosynthetic process involved in glucose fermentation to ethanol. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADH5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (533762..534817)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation termination factor eRF1 Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRPS9 Neighboring gene cationic amino acid transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kluyveromyces marxianus exhibits an ancestral Saccharomyces cerevisiae genome organization downstream of ADH2. Ladrière JM, et al. Gene, 2000 Sep 5. PMID 10974568
    2. NADP-dependent alcohol dehydrogenases in bacteria and yeast: purification and partial characterization of the enzymes from Acinetobacter calcoaceticus and Saccharomyces cerevisiae. Wales MR, et al. Microbiology (Reading), 1994 Jan. PMID 8162187
    3. Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol. Plapp BV, et al. Arch Biochem Biophys, 2016 Feb 1. PMID 26743849
    4. Microbial synergy via an ethanol-triggered pathway. Smith MG, et al. Mol Cell Biol, 2004 May. PMID 15082781, Free PMC Article
    5. Yeast alcohol dehydrogenase: molecular weight, coenzyme binding, and reaction equilibria. HAYES JE Jr, et al. J Biol Chem, 1954 Mar. PMID 13152098

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycolytic fermentation to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    alcohol dehydrogenase ADH5
    NP_009703.3
    • Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      533762..534817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178493.3 → NP_009703.3  TPA: alcohol dehydrogenase ADH5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009703.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQE0, P38113
      UniProtKB/TrEMBL
      A0A6A5Q047, A6ZL87, B3LN13, B5VEA1, C7GY26, D3UEP0, G2W9E7, N1PAT7
      Conserved Domains (1) summary
      cd08297
      Location:10 → 347
      CAD3; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38113.1

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