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    PDH1 putative 2-methylcitrate dehydratase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856108, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PDH1
    Official Full Name
    putative 2-methylcitrate dehydratase
    Primary source
    SGD:S000006206
    Locus tag
    YPR002W
    See related
    AllianceGenome:SGD:S000006206; FungiDB:YPR002W; VEuPathDB:YPR002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and 2-methylcitrate dehydratase activity. Involved in propionate metabolic process. Located in mitochondrial outer membrane. Orthologous to human ACOD1 (aconitate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PDH1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (558385..559935)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase catalytic subunit HAT1 Neighboring gene citrate (Si)-synthase CIT3 Neighboring gene tRNA-Phe Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast mitochondrial proteome, a study of fermentative and respiratory growth. Ohlmeier S, et al. J Biol Chem, 2004 Feb 6. PMID 14597615
    2. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. Horswill AR, et al. J Bacteriol, 1997 Feb. PMID 9006051, Free PMC Article
    3. Genome-wide responses to mitochondrial dysfunction. Epstein CB, et al. Mol Biol Cell, 2001 Feb. PMID 11179416, Free PMC Article
    4. Interactomic study on interaction between lipid droplets and mitochondria. Pu J, et al. Protein Cell, 2011 Jun. PMID 21748599, Free PMC Article
    5. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-methylcitrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in propionate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in propionate metabolic process, methylcitrate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    putative 2-methylcitrate dehydratase
    NP_015326.1
    • Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      558385..559935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184099.1 → NP_015326.1  TPA: putative 2-methylcitrate dehydratase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015326.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W413, Q12428
      UniProtKB/TrEMBL
      A6ZWP7, B3LL63, B5VTG2, C7GV44, C8ZJ27, G2WPI1, N1NW72
      Conserved Domains (1) summary
      PRK09425
      Location:27 → 513
      prpD; bifunctional 2-methylcitrate dehydratase/aconitate hydratase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12428.1

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