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    ODC1 mitochondrial 2-oxodicarboxylate carrier [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855969, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ODC1
    Gene description
    mitochondrial 2-oxodicarboxylate carrier
    Primary source
    FungiDB:YPL134C
    Locus tag
    YPL134C
    See related
    SGD:S000006055; AllianceGenome:SGD:S000006055; VEuPathDB:YPL134C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dicarboxylic acid transmembrane transporter activity. Involved in mitochondrial transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ODC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (298571..299503, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator GIP3 Neighboring gene iron-binding protein ISU1 Neighboring gene gluconeogenesis transcription factor RDS2 Neighboring gene Cox11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deregulating mitochondrial metabolite and ion transport has beneficial effects in yeast and human cellular models for NARP syndrome. Su X, et al. Hum Mol Genet, 2019 Nov 15. PMID 31276579
    2. Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome. de Taffin de Tilques M, et al. Dis Model Mech, 2017 Apr 1. PMID 28188263, Free PMC Article
    3. Yeast mitochondrial oxodicarboxylate transporters are important for growth on oleic acid. Tibbetts AS, et al. Arch Biochem Biophys, 2002 Oct 1. PMID 12234495
    4. Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate. Palmieri L, et al. J Biol Chem, 2001 Jan 19. PMID 11013234
    5. Three mitochondrial transporters of Saccharomyces cerevisiae are essential for ammonium fixation and lysine biosynthesis in synthetic minimal medium. Scarcia P, et al. Mol Genet Metab, 2017 Nov. PMID 28784321

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the suppression of the respiratory-growth-deficient fmc1 by the overexpressed Odc1p was not due to a restored stable ATP synthase.
      Title: Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-aspartate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-glutamate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate-aspartate shuttle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 2-oxodicarboxylate carrier
    NP_015191.1
    • Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      298571..299503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183948.1 → NP_015191.1  TPA: mitochondrial 2-oxodicarboxylate carrier [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3N3, Q03028
      UniProtKB/TrEMBL
      A0A6A5Q573, A6ZWB8, B3LKU1, B5VT31, C7GJ87, C8ZIP6, G2WP47, N1NX22
      Conserved Domains (2) summary
      PTZ00169
      Location:11 → 302
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:8 → 113
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03028.1

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