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    VMA11 H(+)-transporting V0 sector ATPase subunit c' [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855842, updated on 29-Jun-2024

    Summary

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    Gene symbol
    VMA11
    Gene description
    H(+)-transporting V0 sector ATPase subunit c'
    Primary source
    FungiDB:YPL234C
    Locus tag
    YPL234C
    See related
    SGD:S000006155; AllianceGenome:SGD:S000006155; VEuPathDB:YPL234C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS9; TFP3
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in vacuolar acidification. Located in fungal-type vacuole. Is integral component of membrane. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VMA11 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (104946..105440, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative serine/threonine protein kinase ENV7 Neighboring gene RuvB family ATP-dependent DNA helicase reptin Neighboring gene MIND complex subunit NSL1 Neighboring gene syntaxin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Identification of Genes Involved in General Acid Stress and Fluoride Toxicity in Saccharomyces cerevisiae. Johnston NR, et al. Front Microbiol, 2020. PMID 32670247, Free PMC Article
    2. Expression of a proteolipid gene from a high-copy-number plasmid confers trifluoperazine resistance to Saccharomyces cerevisiae. Shih CK, et al. Mol Cell Biol, 1990 Jul. PMID 2192255, Free PMC Article
    3. VMA11, a novel gene that encodes a putative proteolipid, is indispensable for expression of yeast vacuolar membrane H(+)-ATPase activity. Umemoto N, et al. J Biol Chem, 1991 Dec 25. PMID 1837023
    4. Interacting helical surfaces of the transmembrane segments of subunits a and c' of the yeast V-ATPase defined by disulfide-mediated cross-linking. Kawasaki-Nishi S, et al. J Biol Chem, 2003 Oct 24. PMID 12917411
    5. Evolution of increased complexity in a molecular machine. Finnigan GC, et al. Nature, 2012 Jan 9. PMID 22230956, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H(+)-transporting V0 sector ATPase subunit c'
    NP_015090.1
    • Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      104946..105440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184048.1 → NP_015090.1  TPA: H(+)-transporting V0 sector ATPase subunit c' [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3D6, P32365, P32842
      UniProtKB/TrEMBL
      A0A6A5Q2E5, A6ZW21, B3LKJ7, B5VSU8, C7GU73, C8ZIE5, G2WNV1, N1NW63
      Conserved Domains (2) summary
      cd18176
      Location:92 → 159
      ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
      cl00466
      Location:17 → 124
      ATP-synt_C; ATP synthase subunit C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32842.1

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