PDR5 ATP-binding cassette multidrug transporter PDR5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PDR5
Gene description: ATP-binding cassette multidrug transporter PDR5
Primary source: FungiDB:YOR153W
Locus tag: YOR153W
See related: SGD:S000005679; AllianceGenome:SGD:S000005679; VEuPathDB:YOR153W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LEM1; STS1; YDR1
Summary: Enables ABC-type xenobiotic transporter activity. Involved in cellular cation homeostasis; response to xenobiotic stimulus; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in plasma membrane. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA3 (ATP binding cassette subfamily A member 3); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PDR5 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (619840..624375)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A New Twist in ABC Transporter Mediated Multidrug Resistance - Pdr5 is a Drug/proton Co-transporter.
Title: A New Twist in ABC Transporter Mediated Multidrug Resistance - Pdr5 is a Drug/proton Co-transporter.
Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
Title: Yeast Double Transporter Gene Deletion Library for Identification of Xenobiotic Carriers in Low or High Throughput.
RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in rho(0) cells of Saccharomyces cerevisiae.
Title: RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in ρ(0) cells of Saccharomyces cerevisiae.
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
Title: Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5.
In vitro NTPase activity of highly purified Pdr5, a major yeast ABC multidrug transporter.
Title: In vitro NTPase activity of highly purified Pdr5, a major yeast ABC multidrug transporter.
Pdr5 has a newly discovered RNA stability element within its coding region.
Title: Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element.
Sequence comparison between the target proteins, i.e., the plant EPSPS and the yeast orthologous protein Aro1, predicted that yeast would be resistant to glyphosate. However, the growth variation seen in the subset of yeast tested was not due to polymorphisms within Aro1, instead, it was caused by genetic variation in an ABC multiple drug transporter, Pdr5, and an amino acid permease, Dip5
Title: Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.
These results present new evidence, suggesting that transmembrane helix 2 plays an important role for the efflux function of Pdr5p.
Title: Mutations of charged amino acids at the cytoplasmic end of transmembrane helix 2 affect transport activity of the budding yeast multidrug resistance protein Pdr5p.
structural and functional implications for Pdr5
Title: Transmitting the energy: interdomain cross-talk in Pdr5.
High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast.
Title: High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ABC-type xenobiotic transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular monoatomic cation homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular monoatomic cation homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
involved_in response to cycloheximide	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette multidrug transporter PDR5

NP_014796.3

Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

619840..624375

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183572.3 → NP_014796.3 TPA: ATP-binding cassette multidrug transporter PDR5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014796.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2L0, P33302

UniProtKB/TrEMBL

A0A8H4BVR8, G2WN25, N1NYH8

Conserved Domains (2) summary

TIGR00956
Location:100 → 1503

3a01205; Pleiotropic Drug Resistance (PDR) Family protein

pfam14510
Location:46 → 152

ABC_trans_N; ABC-transporter extracellular N-terminal