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    PAI3 Pai3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855212, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAI3
    Official Full Name
    Pai3p
    Primary source
    SGD:S000004786
    Locus tag
    YMR174C
    See related
    AllianceGenome:SGD:S000004786; FungiDB:YMR174C; VEuPathDB:YMR174C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endopeptidase inhibitor activity. Involved in protein catabolic process in the vacuole. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PAI3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (610159..610365, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Hot1p Neighboring gene DNA damage-responsive protein 48 Neighboring gene uncharacterized protein Neighboring gene Sip18p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative structure activity relationship of IA3-like peptides as aspartic proteinase inhibitors. Padrón-García JA, et al. Proteins, 2009 Jun. PMID 19003993
    2. N-terminal extension of the yeast IA3 aspartic proteinase inhibitor relaxes the strict intrinsic selectivity. Winterburn TJ, et al. FEBS J, 2007 Jul. PMID 17608726
    3. Key features determining the specificity of aspartic proteinase inhibition by the helix-forming IA3 polypeptide. Winterburn TJ, et al. J Biol Chem, 2007 Mar 2. PMID 17145748
    4. Adaptation of the behaviour of an aspartic proteinase inhibitor by relocation of a lysine residue by one helical turn. Winterburn TJ, et al. Biol Chem, 2006 Aug. PMID 16895485
    5. The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae. Phylip LH, et al. J Biol Chem, 2001 Jan 19. PMID 11042188

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein catabolic process in the vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pai3p
    NP_013899.1
    • Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      610159..610365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182680.1 → NP_013899.1  TPA: Pai3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013899.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZZ6, P01094
      UniProtKB/TrEMBL
      A6ZMN3, B3LM60, C7GTS7, C8ZF36, G2WKM7, N1P0F8
      Conserved Domains (1) summary
      pfam10466
      Location:1 → 68
      Inhibitor_I34; Saccharopepsin inhibitor I34
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01094.1

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