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    ERG5 C-22 sterol desaturase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855029, updated on 7-Jul-2024

    Summary

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    Gene symbol
    ERG5
    Gene description
    C-22 sterol desaturase
    Primary source
    FungiDB:YMR015C
    Locus tag
    YMR015C
    See related
    SGD:S000004617; AllianceGenome:SGD:S000004617; VEuPathDB:YMR015C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CYP61
    Summary
    Enables C-22 sterol desaturase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to several human genes including CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ERG5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (300869..302485, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Bud22p Neighboring gene Sok2p Neighboring gene Spo20p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses. Liu G, et al. FEMS Yeast Res, 2017 Sep 1. PMID 28910986
    2. Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae. Su W, et al. PLoS One, 2015. PMID 26098102, Free PMC Article
    3. Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents. Kelly SL, et al. J Biol Chem, 1997 Apr 11. PMID 9092539
    4. Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis. Skaggs BA, et al. Gene, 1996 Feb 22. PMID 8635732
    5. Purification and reconstitution of activity of Saccharomyces cerevisiae P450 61, a sterol delta 22-desaturase. Kelly SL, et al. FEBS Lett, 1995 Dec 18. PMID 8543054

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables C-22 sterol desaturase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-22 sterol desaturase
    NP_013728.1
    • C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      300869..302485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182511.1 → NP_013728.1  TPA: C-22 sterol desaturase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013728.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI9, E9P965, P54781
      UniProtKB/TrEMBL
      A0A6A5PQ83, A6ZM77, B3LLR7, B5VPE2, C7GLA4, C8ZEM3, G2WK66, N1NX58
      Conserved Domains (1) summary
      cd11082
      Location:103 → 522
      CYP61_CYP710; C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 710
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54781.1

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