Cenpb centromere protein B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenpbprovided by RGD
Official Full Name: centromere protein Bprovided by RGD
Primary source: RGD:1304794
See related: EnsemblRapid:ENSRNOG00000057284 AllianceGenome:RGD:1304794
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity. Predicted to be located in condensed chromosome, centromeric region; nuclear body; and pericentric heterochromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138850003..138852796, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (118396987..118399780, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123720888..123723520, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: major centromere autoantigen B

Names: centromere autoantigen B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399319.1 → NP_001386248.1 major centromere autoantigen B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2KAW9

Related

ENSRNOP00000075557.2, ENSRNOT00000080351.3

Conserved Domains (4) summary

smart00674
Location:74 → 135

CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases

pfam09026
Location:543 → 602

CENP-B_dimeris; Centromere protein B dimerization domain

pfam03184
Location:222 → 384

DDE_1; DDE superfamily endonuclease

pfam04218
Location:2 → 56

CENP-B_N; CENP-B N-terminal DNA-binding domain