Tacc3 transforming, acidic coiled-coil containing protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tacc3provided by RGD
Official Full Name: transforming, acidic coiled-coil containing protein 3provided by RGD
Primary source: RGD:1302948
See related: EnsemblRapid:ENSRNOG00000017259 AllianceGenome:RGD:1302948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Thymus (RPKM 221.5), Spleen (RPKM 155.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (81275755..81289894, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (77051209..77065343, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82336283..82350069, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142009 (e-PCR)
- UniSTS:224000

D12S364 (e-PCR), detects polymorphism
- UniSTS:30480

BE106930 (e-PCR)
- UniSTS:261699

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within astral microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic sequestering of transcription factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in metaphase/anaphase transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization involved in mitosis	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming acidic coiled-coil-containing protein 3

Names: transforming acidic coiled coil 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004424.3 → NP_001004424.3 transforming acidic coiled-coil-containing protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I5ZK91, A0A8I6ATD8

Related

ENSRNOP00000097835.1, ENSRNOT00000103703.2

Conserved Domains (2) summary

PHA03247
Location:137 → 381

PHA03247; large tegument protein UL36; Provisional

pfam05010
Location:387 → 580

TACC; Transforming acidic coiled-coil-containing protein (TACC)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

81275755..81289894 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251329.4 → XP_006251391.2 transforming acidic coiled-coil-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y652, A0A8I5ZK91

Related

ENSRNOP00000076588.1, ENSRNOT00000097797.2

Conserved Domains (2) summary

PHA03247
Location:248 → 492

PHA03247; large tegument protein UL36; Provisional

pfam05010
Location:498 → 691

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_006251330.5 → XP_006251392.2 transforming acidic coiled-coil-containing protein 3 isoform X2

UniProtKB/TrEMBL

D3Z962

Conserved Domains (2) summary

PRK03427
Location:263 → 371

PRK03427; cell division protein ZipA; Provisional

pfam05010
Location:498 → 616

TACC; Transforming acidic coiled-coil-containing protein (TACC)
XM_063273388.1 → XP_063129458.1 transforming acidic coiled-coil-containing protein 3 isoform X3
XM_039092209.2 → XP_038948137.1 transforming acidic coiled-coil-containing protein 3 isoform X4

Conserved Domains (1) summary

NF033804
Location:261 → 389

Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin