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    HUNK hormonally up-regulated Neu-associated kinase [ Homo sapiens (human) ]

    Gene ID: 30811, updated on 3-Nov-2024

    Summary

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    Official Symbol
    HUNKprovided by HGNC
    Official Full Name
    hormonally up-regulated Neu-associated kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:13326
    See related
    Ensembl:ENSG00000142149 MIM:606532; AllianceGenome:HGNC:13326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta (RPKM 1.4), colon (RPKM 1.2) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HUNK in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (31873020..32004064)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30241343..30372246)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33245333..33376377)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33104777-33105416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33104135-33104776 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33106899-33107074 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33119263-33119514 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:33126139-33126731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33172518-33173018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33173019-33173519 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33200433-33200620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33253321-33253821 Neighboring gene TPT1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33280341-33280874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33284969-33285779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:33303660-33304223 Neighboring gene NANOG hESC enhancer GRCh37_chr21:33315105-33315606 Neighboring gene NANOG hESC enhancer GRCh37_chr21:33346858-33347382 Neighboring gene long intergenic non-protein coding RNA 159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33506465-33506966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18359 Neighboring gene MIS18 kinetochore protein A Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33650609-33651110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33651111-33651610

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1. Han X, et al. Cell Death Dis, 2023 May 16. PMID 37193711, Free PMC Article
    2. [Proteinkinase MAK-V/Hunk as a possible dianostic and prognostic marker of human breast carcinoma]. Korobko IV, et al. Arkh Patol, 2004 Sep-Oct. PMID 15575376
    3. Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression. Zambrano JN, et al. Pharmacol Res, 2017 May. PMID 28189783, Free PMC Article
    4. The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Wertheim GB, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19717424, Free PMC Article
    5. HUNK Phosphorylates Rubicon to Support Autophagy. Zambrano JN, et al. Int J Mol Sci, 2019 Nov 19. PMID 31752345, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.
      Title: HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.
    2. HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.
      Title: HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.
    3. HUNK phosphorylates EGFR to regulate breast cancer metastasis.
      Title: HUNK phosphorylates EGFR to regulate breast cancer metastasis.
    4. Rubicon as a novel substrate of HUNK.
      Title: HUNK Phosphorylates Rubicon to Support Autophagy.
    5. Recent work demonstrates a role for Hunk in HER2(+)/ErbB2(+) breast cancer progression, including drug resistance to HER2/ErbB2 inhibitors, with Hunk potentially acting downstream of HER2/ErbB2 and the PI3K/Akt pathway. [review]
      Title: Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.
    6. Our findings indicate that therapeutically targeting HUNK is a potential strategy for overcoming resistance and that resistant breast cancer cells maintain HUNK expression to drive tumorigenesis
      Title: Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors.
    7. Hunk is required for HER2/neu-induced mammary tumorigenesis
      Title: Hunk is required for HER2/neu-induced mammary tumorigenesis.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Data show that HUNK reconstitution in basal breast cancer cell lines prevented protein phosphatase 2-A (PP2A from binding to CFL-1.
      Title: HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.
    10. a gene expression signature that distinguishes Hunk-wild type from Hunk-deficient tumors predicts clinical outcome in women with breast cancer
      Title: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hormonally up-regulated neu tumor-associated kinase
    Names
    B19
    hormonally upregulated Neu-associated kinase
    hormonally upregulated neu tumor-associated kinase
    serine/threonine protein kinase MAK-V
    NP_055401.1
    XP_011527839.1
    XP_054180424.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014586.2 → NP_055401.1  hormonally up-regulated neu tumor-associated kinase

      See identical proteins and their annotated locations for NP_055401.1

      Status: VALIDATED

      Source sequence(s)
      AJ271722, AP000256
      Consensus CDS
      CCDS13610.1
      UniProtKB/Swiss-Prot
      P57058
      Related
      ENSP00000270112.2, ENST00000270112.7
      Conserved Domains (2) summary
      smart00220
      Location:61 → 320
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14070
      Location:58 → 320
      STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      31873020..32004064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529537.3 → XP_011527839.1  hormonally up-regulated neu tumor-associated kinase isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:61 → 320
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14070
      Location:58 → 320
      STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      30241343..30372246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324449.1 → XP_054180424.1  hormonally up-regulated neu tumor-associated kinase isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57058.1 GenPept UniProtKB/Swiss-Prot:P57058

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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