STK26 serine/threonine kinase 26 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STK26provided by HGNC
Official Full Name: serine/threonine kinase 26provided by HGNC
Primary source: HGNC:HGNC:18174
See related: Ensembl:ENSG00000134602 MIM:300547; AllianceGenome:HGNC:18174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MASK; MST4
Summary: The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression: Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq26.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (132023302..132075943)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (130347539..130400176)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (131157330..131209971)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
Title: Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
Title: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
Title: STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.
Title: The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.
MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
Title: MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
Title: An MST4-pβ-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
Title: A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway.
Title: Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway.
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
Title: MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.
Title: Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH120536 (e-PCR)
- UniSTS:133701

RH65695 (e-PCR)
- UniSTS:65096

RH16585 (e-PCR)
- UniSTS:53890

AL035152 (e-PCR)
- UniSTS:94631

AL035147 (e-PCR)
- UniSTS:94660

WI-11835 (e-PCR)
- UniSTS:21460

WI-16556 (e-PCR)
- UniSTS:45781

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microvillus assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase 26

Names: Mst3 and SOK1-related kinase; STE20-like kinase 4; STE20-like kinase MST4; mammalian Ste20-like protein kinase 4; mammalian sterile 20-like 4; serine/threonine protein kinase 26; serine/threonine protein kinase MST4; serine/threonine-protein kinase MASK

NP_001035917.1

EC 2.7.11.1

NP_001035918.1

EC 2.7.11.1

NP_057626.2

EC 2.7.11.1

XP_047298111.1

EC 2.7.11.1

XP_047298112.1

EC 2.7.11.1

XP_054183158.1

EC 2.7.11.1

XP_054183159.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029562.1 RefSeqGene

Range

5086..57727

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001042452.2 → NP_001035917.1 serine/threonine-protein kinase 26 isoform 3

See identical proteins and their annotated locations for NP_001035917.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1, and lacks kinase activity.

Source sequence(s)

AF344883, AL109749, BC070056

Consensus CDS

CCDS43995.1

UniProtKB/TrEMBL

Q499L9

Related

ENSP00000419702.1, ENST00000496850.1

Conserved Domains (1) summary

cl21453
Location:19 → 233

PKc_like; Protein Kinases, catalytic domain
NM_001042453.2 → NP_001035918.1 serine/threonine-protein kinase 26 isoform 2

See identical proteins and their annotated locations for NP_001035918.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AK075107, BC070056, DA760264

Consensus CDS

CCDS48168.1

UniProtKB/TrEMBL

Q9NWX4

Related

ENSP00000377868.2, ENST00000394335.6

Conserved Domains (1) summary

cl21453
Location:15 → 218

PKc_like; Protein Kinases, catalytic domain
NM_016542.4 → NP_057626.2 serine/threonine-protein kinase 26 isoform 1

See identical proteins and their annotated locations for NP_057626.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).

Source sequence(s)

AF231012, BC070056, DA760264

Consensus CDS

CCDS14631.1

UniProtKB/Swiss-Prot

B2RAU2, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4, Q9P289

UniProtKB/TrEMBL

Q499L9

Related

ENSP00000377867.2, ENST00000394334.7

Conserved Domains (1) summary

cd06640
Location:19 → 295

STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4