Fads2 fatty acid desaturase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fads2provided by RGD
Official Full Name: fatty acid desaturase 2provided by RGD
Primary source: RGD:68339
See related: EnsemblRapid:ENSRNOG00000020440 AllianceGenome:RGD:68339
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fadsd6
Summary: Predicted to enable stearoyl-CoA 9-desaturase activity. Involved in arachidonate metabolite production involved in inflammatory response and positive regulation of cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum membrane. Used to study congestive heart failure and discrete subaortic stenosis. Biomarker of congestive heart failure and type 1 diabetes mellitus. Orthologous to human FADS2 (fatty acid desaturase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1033.9), Adrenal (RPKM 684.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216132277..216172190, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (206707384..206747333, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225906582..226152568, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of dietary plant extracts and vegetable oils on hepatic SREBP-1c, Delta5 and Delta6 desaturases has been reported.
Title: Adding a purple corn extract in rats supplemented with chia oil decreases gene expression of SREBP-1c and retains Δ5 and Δ6 hepatic desaturase activity, unmodified the hepatic lipid profile.
We first showed that both recombinant and native rat FADS2 were able to Delta6-desaturate not only the cis9- but also the cis12- and cis15-18:1 isomers.
Title: Influence of the cis-9, cis-12 and cis-15 double bond position in octadecenoic acid (18:1) isomers on the rat FADS2-catalyzed Δ6-desaturation.
Results show that genes with the highest expression in the mammary gland, liver and adipose tissue were Elovl5, Fads2, and Fasn, respectively, in a low-lipid diet than in adequate-lipid diet.
Title: Role of maternal tissue in the synthesis of polyunsaturated fatty acids in response to a lipid-deficient diet during pregnancy and lactation in rats.
Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure.
Title: Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure.
epigenetic regulation of Fads2 may contribute to short- and long-term regulation of PUFA synthesis
Title: Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver.
Changes in progesterone and oestradiol during pregnancy may promote the synthesis of LC PUFA via increased FADS2 expression.
Title: Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression.
Data show that an imbalance of maternal micronutrients increases Delta5 desaturase activity but decreases mRNA levels, decreases Delta6 desaturase activity but not mRNA levels as compared to control.
Title: Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats.
Results show that delta-6 desaturase as well as elongase-6 expressions were upregulated in 3-month-old Zucker fatty rats as compared to lean littermates.
Title: The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
Regulation of 6-desaturase expression is different in female vs. male liver (but not cerebral cortex) during n-3 fatty acid repletion.
Title: Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion.
n-6 and n-3 PUFAs suppressed the hepatic expression of Fads2 by inhibiting the rate of Fads2 gene transcription. In contrast, consumption of the PPARalpha activator WY 14,643 significantly enhanced the transcription of hepatic DeFads2 by 500%.
Title: Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

Fads2 (e-PCR), detects polymorphism
- UniSTS:546766

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables linoleoyl-CoA desaturase activity	IEA Inferred from Electronic Annotation more info
enables omega-6 fatty acid desaturase activity	TAS Traceable Author Statement more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IEA Inferred from Electronic Annotation more info
enables stearoyl-CoA 9-desaturase activity	ISO Inferred from Sequence Orthology more info
enables stearoyl-CoA 9-desaturase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolite production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: acyl-CoA 6-desaturase

Names: D6D; delta(6) desaturase; delta-6 fatty acid desaturase; fatty acid desaturase 6

NP_112634.1

EC 1.14.19.3

XP_008758466.1

EC 1.14.19.3

XP_038948408.1

EC 1.14.19.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031344.2 → NP_112634.1 acyl-CoA 6-desaturase

See identical proteins and their annotated locations for NP_112634.1

Status: PROVISIONAL

Source sequence(s)

BC081776

UniProtKB/Swiss-Prot

H2BF31, Q9Z122

UniProtKB/TrEMBL

A0A8I5ZWZ8, A6I009

Related

ENSRNOP00000027756.6, ENSRNOT00000027756.8

Conserved Domains (2) summary

PLN03198
Location:20 → 435

PLN03198; delta6-acyl-lipid desaturase; Provisional

cd03506
Location:162 → 412

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

216132277..216172190 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092480.2 → XP_038948408.1 acyl-CoA 6-desaturase isoform X1

UniProtKB/TrEMBL

A0A8I5ZWZ8, A0A8I6A6F8

Related

ENSRNOP00000088570.1, ENSRNOT00000120292.2

Conserved Domains (2) summary

cd03506
Location:125 → 375

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00173
Location:22 → 69

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
XM_008760244.3 → XP_008758466.1 acyl-CoA 6-desaturase isoform X2

UniProtKB/TrEMBL

A0A8I5ZWZ8

Conserved Domains (2) summary

cd03506
Location:97 → 347

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00487
Location:92 → 353

FA_desaturase; Fatty acid desaturase