Pigt phosphatidylinositol glycan anchor biosynthesis, class T [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pigtprovided by RGD
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Tprovided by RGD
Primary source: RGD:1307156
See related: EnsemblRapid:ENSRNOG00000014690 AllianceGenome:RGD:1307156
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in attachment of GPI anchor to protein. Predicted to act upstream of or within neuron apoptotic process and neuron differentiation. Predicted to be located in cytoplasmic vesicle. Predicted to be part of GPI-anchor transamidase complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 3 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGT (phosphatidylinositol glycan anchor biosynthesis class T). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 84.8), Lung (RPKM 67.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173647104..173656269)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153227749..153236922)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160945556..160954738)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of GPI anchor to protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GPI transamidase component PIG-T

Names: phosphatidylinositol glycan, class T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106540.2 → NP_001100010.2 GPI transamidase component PIG-T isoform 1 precursor

See identical proteins and their annotated locations for NP_001100010.2

Status: PROVISIONAL

Source sequence(s)

CH474005

UniProtKB/TrEMBL

A6JX95, D4A604

Related

ENSRNOP00000090741.1, ENSRNOT00000117035.2

Conserved Domains (1) summary

pfam04113
Location:34 → 565

Gpi16; Gpi16 subunit, GPI transamidase component
NM_001430209.1 → NP_001417138.1 GPI transamidase component PIG-T isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

173647104..173656269

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235532.5 → XP_006235594.2 GPI transamidase component PIG-T isoform X1

Conserved Domains (1) summary

pfam04113
Location:34 → 566

Gpi16; Gpi16 subunit, GPI transamidase component