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    Usp37 ubiquitin specific peptidase 37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361658, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Usp37provided by RGD
    Official Full Name
    ubiquitin specific peptidase 37provided by RGD
    Primary source
    RGD:2319715
    See related
    EnsemblRapid:ENSRNOG00000022720 AllianceGenome:RGD:2319715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and protein kinase binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 132.7), Thymus (RPKM 107.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp37 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83467966..83567848, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76018863..76118732, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81717626..81818421, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene transfer RNA proline (anticodon AGG) 59 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication. Hernández-Pérez S, et al. Mol Oncol, 2016 Oct. PMID 27296872, Free PMC Article
    2. Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Huang X, et al. Mol Cell, 2011 May 20. PMID 21596315
    3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 37
    Names
    ubiquitin specific protease 37
    NP_001414600.1
    XP_006245354.1
    XP_006245355.1
    XP_006245356.1
    XP_006245357.1
    XP_006245358.1
    XP_008765529.1
    XP_063122570.1
    XP_063122571.1
    XP_063122572.1
    XP_063122573.1
    XP_063122574.1
    XP_063122575.1
    XP_063122576.1
    XP_063122577.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427671.1 → NP_001414600.1  ubiquitin carboxyl-terminal hydrolase 37

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4ABE5
      Related
      ENSRNOP00000033308.1, ENSRNOT00000032719.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83467966..83567848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266507.1 → XP_063122577.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X6

    2. XM_063266503.1 → XP_063122573.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

      UniProtKB/TrEMBL
      A0A8I6B2I8

    3. XM_063266501.1 → XP_063122571.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    4. XM_008767307.4 → XP_008765529.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_008765529.1

      UniProtKB/TrEMBL
      A0A8I6GH62, D4ABE5
      Conserved Domains (3) summary
      cd02257
      Location:342 → 603
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    5. XM_006245293.5 → XP_006245355.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_006245355.1

      UniProtKB/TrEMBL
      A0A8I6GH62, D4ABE5
      Conserved Domains (3) summary
      cd02257
      Location:342 → 603
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    6. XM_063266500.1 → XP_063122570.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/TrEMBL
      D4ABE5

    7. XM_063266506.1 → XP_063122576.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X6

    8. XM_063266505.1 → XP_063122575.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X5

    9. XM_063266502.1 → XP_063122572.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X3

    10. XM_006245295.5 → XP_006245357.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

      See identical proteins and their annotated locations for XP_006245357.1

      UniProtKB/TrEMBL
      A0A8I6GH62
      Conserved Domains (3) summary
      cd02257
      Location:342 → 603
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    11. XM_006245296.4 → XP_006245358.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

      See identical proteins and their annotated locations for XP_006245358.1

      UniProtKB/TrEMBL
      A0A8I6B2I8, A0A8I6GH62
      Related
      ENSRNOP00000095391.1, ENSRNOT00000107297.2
      Conserved Domains (3) summary
      cd02257
      Location:342 → 603
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    12. XM_006245292.5 → XP_006245354.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_006245354.1

      UniProtKB/TrEMBL
      A0A8I6GH62, D4ABE5
      Conserved Domains (3) summary
      cd02257
      Location:342 → 603
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    13. XM_063266504.1 → XP_063122574.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

      UniProtKB/TrEMBL
      A0A8I6B2I8

    14. XM_006245294.5 → XP_006245356.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      See identical proteins and their annotated locations for XP_006245356.1

      UniProtKB/TrEMBL
      A0A8I6GH62, D4ABE5
      Conserved Domains (3) summary
      cd02257
      Location:342 → 603
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:342 → 600
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3 → 104
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
    Nucleotide Protein Strain
    Heading Accession and Version

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