Ucp3 uncoupling protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ucp3provided by RGD
Official Full Name: uncoupling protein 3provided by RGD
Primary source: RGD:3933
See related: EnsemblRapid:ENSRNOG00000017716 AllianceGenome:RGD:3933
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in several processes, including response to fenofibrate; response to insulin; and response to superoxide. Predicted to be located in mitochondrial inner membrane. Used to study type 2 diabetes mellitus. Biomarker of congestive heart failure; hypertension; hyperthyroidism; hypothyroidism; and prediabetes syndrome. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Muscle (RPKM 343.4), Heart (RPKM 56.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164227910..164240893)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154815777..154828764)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (165482912..165495895)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we demonstrated that normal cardiac UCP3 levels are essential to recovery of long-chain fatty acid oxidation, mitochondrial respiratory capacity, and contractile function following cardiac ischemia/reperfusion
Title: Uncoupling protein 3 deficiency impairs myocardial fatty acid oxidation and contractile recovery following ischemia/reperfusion.
Data suggest that UCP3 expression, energy metabolism, and uptake/beta-oxidation of free fatty acids in skeletal muscle can be regulated by dietary components; here, ursolic acid, a dietary triterpenoid, has anti-obesity effects.
Title: Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and β-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.
Based on Ucp3 content, a decrease in oxidative capacity and proton leak in intermyofibrillar and subsarcolemmal mitochondria could induce a decline in energy expenditure and thus contribute to the reduced resting metabolic rate found in old rats.
Title: Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats.
Endurance training blocked the high-sugar diet induced up-regulation of UCP1 expression in interscapular brown adipose tissue, whereas it up-regulated the expression of Ucp3 mRNA in muscle.
Title: Endurance training blocks uncoupling protein 1 up-regulation in brown adipose tissue while increasing uncoupling protein 3 in the muscle tissue of rats fed with a high-sugar diet.
Examined the effect of D-Asp uptake on the expression of the mitochondrial uncoupling protein-3 (UCP3), beta-actin, and alpha-tubulin in rat Harderian gland.
Title: Effect of D-aspartate uptake on uncoupling protein-3 and α-tubulin expressions in rat Harderian gland.
High fat diets increase the expression of fatty acid oxidation enzymes such as UCP3,PDK4, and MCAD concomitant with elevated plasma fatty acid levels and the induction of PGC-1 beta, but independent of changes in AMPK, p38, and PKA signaling.
Title: Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms.
High-fat diet induced obesity resistance was closely associated with increased UCP2, UCP3, and decreased PPARgamma2 mRNA in white adipose tissue.
Title: [UCPs and PPARgamma2 mRNA in diet induced obesity resistant rats].
These findings indicate that changes in Intramyocellular lipids content but not UCP3 content are implicated in short-term effects of cafeteria-style diet and exercise training on muscular insulin sensitivity in rats.
Title: Hyperglycemic diet and training alter insulin sensitivity, intramyocellular lipid content but not UCP3 protein expression in rat skeletal muscles.
In the mouse C2C12 myoblast cell line, UCP3 has a short half-life of 0.5-4 h. Its turnover is proteasome dependent.
Title: Rapid turnover of mitochondrial uncoupling protein 3.
It is concluded that UCP2 and UCP3 are implicated in the age-depended heart dysfunction and development of the pathological mechanisms during ischemia-reperfusion.
Title: [UCP2 and UCP3 gene expression, heart function and oxygen cost of myocardial work changes during aging and ischemia-reperfusion].

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Markers

UCP3 (e-PCR)
- UniSTS:264964

RH94827 (e-PCR)
- UniSTS:120073

UCP2 (e-PCR)
- UniSTS:504136

D1Wox38 (e-PCR)
- UniSTS:517777

Ucp3 (e-PCR), detects polymorphism
- UniSTS:531402

AW533754 (e-PCR)
- UniSTS:246007

D1Arb16 (e-PCR)
- UniSTS:240127

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid hydroperoxide transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fenofibrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to superoxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to superoxide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: putative mitochondrial transporter UCP3

Names: UCP 3; Uncoupling protein 3, mitochondrial; mitochondrial uncoupling protein 3; solute carrier family 25 member 9; uncoupling protein 3 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013167.2 → NP_037299.1 putative mitochondrial transporter UCP3

See identical proteins and their annotated locations for NP_037299.1

Status: PROVISIONAL

Source sequence(s)

BC072546

UniProtKB/Swiss-Prot

P56499

UniProtKB/TrEMBL

A6I6N5

Related

ENSRNOP00000024005.3, ENSRNOT00000024005.7

Conserved Domains (2) summary

PTZ00169
Location:13 → 298

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:109 → 206

Mito_carr; Mitochondrial carrier protein