RT1-EC2 RT1 class Ib, locus EC2 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: RT1-EC2provided by RGD
Official Full Name: RT1 class Ib, locus EC2provided by RGD
Primary source: RGD:3512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RTS; RT1-A; MHCRTA; RT1.Al; RT1Aw2; RT1-Aw2; RT1.EC2; RATMHCRTA
Annotation information: not in current annotation release
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI235223 (e-PCR)
- UniSTS:250377

H2-K1 (e-PCR), detects polymorphism
- UniSTS:463411

H2-D1 (e-PCR), detects polymorphism
- UniSTS:143300

BI280335 (e-PCR)
- UniSTS:249032

H2-Q6 (e-PCR), detects polymorphism
- UniSTS:143310

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: class I histocompatibility antigen, Non-RT1.A alpha-1 chain

Names: MHC class I antigen; MHC class Ia protein; RT1 class I histocompatibility antigen, AA alpha chain; RT1 class Ib gene RT1Aw2; RT1 class Ib gene(Aw2); RT1 class Ib, locus Aw2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012645.1 → NP_036777.1 class I histocompatibility antigen, Non-RT1.A alpha-1 chain precursor

See identical proteins and their annotated locations for NP_036777.1

Status: PROVISIONAL

Source sequence(s)

M31038

UniProtKB/Swiss-Prot

P15978

UniProtKB/TrEMBL

Q6P764

Conserved Domains (2) summary

cd07698
Location:207 → 299

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:25 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2