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    SLC26A7 solute carrier family 26 member 7 [ Homo sapiens (human) ]

    Gene ID: 115111, updated on 28-Oct-2024

    Summary

    Official Symbol
    SLC26A7provided by HGNC
    Official Full Name
    solute carrier family 26 member 7provided by HGNC
    Primary source
    HGNC:HGNC:14467
    See related
    Ensembl:ENSG00000147606 MIM:608479; AllianceGenome:HGNC:14467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SUT2
    Summary
    This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]
    Expression
    Restricted expression toward thyroid (RPKM 194.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC26A7 in Genome Data Viewer
    Location:
    8q21.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (91209496..91398155)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (92334433..92523083)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92221724..92410383)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 69 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:92209377-92209886 Neighboring gene ceruloplasmin pseudogene Neighboring gene microRNA 4661 Neighboring gene uncharacterized LOC105375637 Neighboring gene NANOG hESC enhancer GRCh37_chr8:92457755-92458322 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:92539517-92540085 Neighboring gene RN7SK pseudogene 231

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: LRRC69

    Clone Names

    • MGC126268

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bicarbonate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chloride channel activity TAS
    Traceable Author Statement
    more info
     
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chloride:bicarbonate antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxalate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bicarbonate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gluconate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in iodide transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in nitrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oxalate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    anion exchange transporter
    Names
    solute carrier family 26 (anion exchanger), member 7
    solute carrier family 6 member 7
    sulfate anion transporter
    sulfate anion transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282356.2NP_001269285.1  anion exchange transporter isoform a

      See identical proteins and their annotated locations for NP_001269285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AF331521, AI758950, BC094730
      Consensus CDS
      CCDS6254.1
      UniProtKB/Swiss-Prot
      Q24JS8, Q8TE53, Q8TE54, Q96RN2
      Related
      ENSP00000428849.1, ENST00000523719.5
      Conserved Domains (2) summary
      cd07042
      Location:495631
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:33637
      sulP; high affinity sulphate transporter 1
    2. NM_001282357.2NP_001269286.1  anion exchange transporter isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 3. This variant represents translation initiation at a downstream AUG; the 5'-most initiation codon, as used in variant 3, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode isoform c.
      Source sequence(s)
      AF331521, AI758950, BC060784, BC094730
      Consensus CDS
      CCDS75765.1
      UniProtKB/TrEMBL
      A0A087WZI7
      Related
      ENSP00000482686.1, ENST00000617078.3
      Conserved Domains (2) summary
      cd07042
      Location:194330
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:2336
      sulP; high affinity sulphate transporter 1
    3. NM_052832.4NP_439897.1  anion exchange transporter isoform a

      See identical proteins and their annotated locations for NP_439897.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AF331521, AI758950, AJ413229, BC094730
      Consensus CDS
      CCDS6254.1
      UniProtKB/Swiss-Prot
      Q24JS8, Q8TE53, Q8TE54, Q96RN2
      Related
      ENSP00000276609.3, ENST00000276609.8
      Conserved Domains (2) summary
      cd07042
      Location:495631
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:33637
      sulP; high affinity sulphate transporter 1
    4. NM_134266.2NP_599028.1  anion exchange transporter isoform b

      See identical proteins and their annotated locations for NP_599028.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate terminal exon, which results in a frameshift, compared to variant 3. The resulting isoform (b) has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC087847, AC104967
      Consensus CDS
      CCDS6255.1
      UniProtKB/Swiss-Prot
      Q8TE54
      Related
      ENSP00000309504.2, ENST00000309536.6
      Conserved Domains (2) summary
      cd07042
      Location:495631
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:33637
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      91209496..91398155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      92334433..92523083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)