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    GPI18 GPI-anchor transamidase GPI18 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852289, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPI18
    Official Full Name
    GPI-anchor transamidase GPI18
    Primary source
    SGD:S000000208
    Locus tag
    YBR004C
    See related
    AllianceGenome:SGD:S000000208; FungiDB:YBR004C; VEuPathDB:YBR004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,6-mannosyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Part of mannosyltransferase complex. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 1. Orthologous to human PIGV (phosphatidylinositol glycan anchor biosynthesis class V). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GPI18 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (244366..245667, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene trans-hexaprenyltranstransferase Neighboring gene Rcr1p Neighboring gene succinate-semialdehyde dehydrogenase (NAD(P)(+))

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pga1 is an essential component of Glycosylphosphatidylinositol-mannosyltransferase II of Saccharomyces cerevisiae. Sato K, et al. Mol Biol Cell, 2007 Sep. PMID 17615295, Free PMC Article
    2. Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly. Fabre AL, et al. FEBS J, 2005 Mar. PMID 15720390
    3. PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. Kang JY, et al. J Biol Chem, 2005 Mar 11. PMID 15623507
    4. Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast. Au WC, et al. PLoS Genet, 2020 Feb. PMID 32032354, Free PMC Article
    5. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,6-mannosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables alpha-1,6-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycolipid mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannosyltransferase complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of mannosyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    GPI-anchor transamidase GPI18
    NP_009558.2
    • Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      244366..245667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178352.2 → NP_009558.2  TPA: GPI-anchor transamidase GPI18 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009558.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ05, P38211, P89496
      UniProtKB/TrEMBL
      G2W912
      Conserved Domains (1) summary
      cl21590
      Location:2 → 433
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38211.2

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