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    DRN1 Drn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852985, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DRN1
    Official Full Name
    Drn1p
    Primary source
    SGD:S000003325
    Locus tag
    YGR093W
    See related
    AllianceGenome:SGD:S000003325; FungiDB:YGR093W; VEuPathDB:YGR093W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA lariat debranching enzyme activator activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See DRN1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (670388..671911)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit PRP31 Neighboring gene serine/threonine-protein kinase DBF2 Neighboring gene valine--tRNA ligase Neighboring gene exosome non-catalytic core subunit RRP46

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A homolog of lariat-debranching enzyme modulates turnover of branched RNA. Garrey SM, et al. RNA, 2014 Aug. PMID 24919400, Free PMC Article
    2. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. Scherz K, et al. G3 (Bethesda), 2014 Jul 9. PMID 25009170, Free PMC Article
    3. The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Dastidar RG, et al. Cell Biosci, 2012 Aug 29. PMID 22932476, Free PMC Article
    4. A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition. Barkova A, et al. Mob DNA, 2022 Nov 18. PMID 36401307, Free PMC Article
    5. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Wilmes GM, et al. Mol Cell, 2008 Dec 5. PMID 19061648, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA lariat debranching enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Drn1p
    NP_011607.3
    • Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      670388..671911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181222.3 → NP_011607.3  TPA: Drn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011607.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUM5, P53255
      UniProtKB/TrEMBL
      A6ZV75, B3LID3, C7GWX0, C8Z8Y7
      Conserved Domains (3) summary
      pfam04676
      Location:414 → 502
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl00228
      Location:256 → 381
      HIT_like; HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis ...
      cl13995
      Location:7 → 190
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53255.1

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