YPK2 putative protein kinase YPK2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YPK2
Official Full Name: putative protein kinase YPK2
Primary source: SGD:S000004710
Locus tag: YMR104C
See related: AllianceGenome:SGD:S000004710; FungiDB:YMR104C; VEuPathDB:YMR104C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YKR2
Summary: Enables protein serine/threonine kinase activity. Involved in eisosome assembly and regulation of fungal-type cell wall organization. Located in nucleus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including C8orf44-SGK3 (C8orf44-SGK3 readthrough); SGK1 (serum/glucocorticoid regulated kinase 1); and SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YPK2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (473420..475453, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show a mechanism through which the conserved Pkh-Ypk kinase cascade and Cdc55-PP2A facilitate rapid, transient sphingolipid production in response to heat stress through Orm protein phosphoregulation.
Title: Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.
Direct Avo1-Ypk2 interaction is crucial for TORC2 signaling to the downstream Ypk2 pathway.
Title: Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae.
endocytosis is regulated by the sphingolipid-Pkh1/2-Ypk1/2 signaling pathway and Pkh1 and -2 respond to changes in membrane sphingolipids and transmit this information to eisosomes via Pil1 phosphorylation
Title: The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover.
cerTORC2 regulates ceramide biosynthesis in part by activating the AGC kinase Ypk2 and this step is antagonized by the Ca2+/calmodulin-dependent phosphatase calcineurin
Title: Regulation of ceramide biosynthesis by TOR complex 2.
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization
Title: Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
phytosphingosine, rather than simply being an upstream activator of Pkh1, also activates kinases that are downstream targets of Pkh1 including Ypk1/2 and Sch9
Title: The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in eisosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of fungal-type cell wall organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative protein kinase YPK2

NP_013822.1

EC 2.7.11.1

AGC-type S/T protein kinase; participates in the cell wall integrity signaling pathway; involved with Ypk1p in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6), and in the direct phosphorylation of the Myo5p motor domain TEDS site; phosphorylated and activated by Pkh1/2p in the presence of phytosphingosine; direct phosphorylation by Tor2p regulates actin polarization; genetically redundant with YPK1; human homolog SGK2 can complement the inviability of a ypk1 ypk2 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

473420..475453 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182604.1 → NP_013822.1 TPA: putative protein kinase YPK2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013822.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZS6, P18961

UniProtKB/TrEMBL

B3LLZ4

Conserved Domains (2) summary

cd11651
Location:114 → 339

YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1

cl21453
Location:349 → 660

PKc_like; Protein Kinases, catalytic domain