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    ARO7 chorismate mutase ARO7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856173, updated on 17-May-2024

    Summary

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    Gene symbol
    ARO7
    Gene description
    chorismate mutase ARO7
    Primary source
    FungiDB:YPR060C
    Locus tag
    YPR060C
    See related
    SGD:S000006264; AllianceGenome:SGD:S000006264
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HGS1; OSM2; TYR7
    Summary
    Enables chorismate mutase activity. Involved in L-phenylalanine biosynthetic process and tyrosine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (674861..675631, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Brr1p Neighboring gene organic acid transporter Neighboring gene Jid1p Neighboring gene cytosine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel chorismate mutase from Erysiphe quercicola performs dual functions of synthesizing amino acids and inhibiting plant salicylic acid synthesis. He Q, et al. Microbiol Res, 2021 Jan. PMID 33010586
    2. The allosteric mechanism of yeast chorismate mutase: a dynamic analysis. Kong Y, et al. J Mol Biol, 2006 Feb 10. PMID 16337651
    3. Refined molecular hinge between allosteric and catalytic domain determines allosteric regulation and stability of fungal chorismate mutase. Helmstaedt K, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 11997452, Free PMC Article
    4. The aroC gene of Aspergillus nidulans codes for a monofunctional, allosterically regulated chorismate mutase. Krappmann S, et al. J Biol Chem, 1999 Aug 6. PMID 10428795
    5. Yeast chorismate mutase in the R state: simulations of the active site. Ma J, et al. Proc Natl Acad Sci U S A, 1998 Dec 8. PMID 9843942, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chorismate mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chorismate mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chorismate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-phenylalanine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    chorismate mutase ARO7
    NP_015385.1
    • Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      674861..675631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184157.1 → NP_015385.1  TPA: chorismate mutase ARO7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W465, P32178
      UniProtKB/TrEMBL
      A0A6A5Q2J8, A6ZWU8, B3LLB4, C7GY46, C8ZJ85, G2WPN3, N1NW21
      Conserved Domains (1) summary
      TIGR01802
      Location:10 → 255
      CM_pl-yst; monofunctional chorismate mutase, eukaryotic type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32178.1

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