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    BNI5 Bni5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855555, updated on 17-May-2024

    Summary

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    Gene symbol
    BNI5
    Gene description
    Bni5p
    Primary source
    FungiDB:YNL166C
    Locus tag
    YNL166C
    See related
    SGD:S000005110; AllianceGenome:SGD:S000005110; VEuPathDB:YNL166C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables myosin II tail binding activity and protein-macromolecule adaptor activity. Involved in protein localization to cell division site and septin ring assembly. Located in cellular bud neck septin ring. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BNI5 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (322219..323565, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Fmp41p Neighboring gene Sko1p Neighboring gene uncharacterized protein Neighboring gene Ibd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of Bni5 phosphorylation for bud morphogenesis in Saccharomyces cerevisiae. Nam SC, et al. J Microbiol, 2007 Feb. PMID 17342053
    2. Effects of Bni5 Binding on Septin Filament Organization. Booth EA, et al. J Mol Biol, 2016 Dec 4. PMID 27806918, Free PMC Article
    3. Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis. Nam SC, et al. J Microbiol, 2007 Jun. PMID 17618228
    4. The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing. Marquardt J, et al. Curr Biol, 2020 Jun 22. PMID 32386534, Free PMC Article
    5. Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II. Fang X, et al. J Cell Biol, 2010 Dec 27. PMID 21173112, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors found that the interaction of Bni5 with the terminal subunit (Cdc11) at the junctions between adjacent hetero-octamers in paired filaments is highly cooperative.
      Title: Effects of Bni5 Binding on Septin Filament Organization.
    2. Bni5 phosphorylation is important for interaction with septin component Cdc11 and for timely delocalization from septin filament at late mitosis.
      Title: Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis.
    3. These results suggest that bud morphogenesis and mitotic entry are positively regulated by phosphorylation-dependent function of Bni5 which is under the control of Swe1 morphogenesis pathway.
      Title: Requirement of Bni5 phosphorylation for bud morphogenesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables myosin II tail binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization to cell division site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bni5p
    NP_014233.1
    • Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      322219..323565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183004.1 → NP_014233.1  TPA: Bni5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014233.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W116, P53890
      UniProtKB/TrEMBL
      A0A6A5Q774, A6ZRR7, C7GTE3, C8ZG62, N1NXS5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53890.1

    Gene LinkOut

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