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    BOS1 Bos1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850767, updated on 28-Oct-2024

    Summary

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    Official Symbol
    BOS1
    Official Full Name
    Bos1p
    Primary source
    SGD:S000004068
    Locus tag
    YLR078C
    See related
    AllianceGenome:SGD:S000004068; FungiDB:YLR078C; VEuPathDB:YLR078C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEC32
    Summary
    Enables SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in ER to Golgi transport vesicle membrane and endoplasmic reticulum membrane. Part of SNARE complex. Used to study progressive myoclonus epilepsy 6. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 6. Orthologous to human GOSR2 (golgi SNAP receptor complex member 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See BOS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (285736..286559, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L10 Neighboring gene Fmp25p Neighboring gene cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 Neighboring gene Emp46p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane. Newman AP, et al. EMBO J, 1992 Oct. PMID 1396561, Free PMC Article
    2. Yeast ER-Golgi v-SNAREs Bos1p and Bet1p differ in steady-state localization and targeting. Ossipov D, et al. J Cell Sci, 1999 Nov. PMID 10547372
    3. Bet1p activates the v-SNARE Bos1p. Stone S, et al. Mol Biol Cell, 1997 Jul. PMID 9243499, Free PMC Article
    4. Ypt1p implicated in v-SNARE activation. Lian JP, et al. Nature, 1994 Dec 15. PMID 7990964
    5. Bos1p, an integral membrane protein of the endoplasmic reticulum to Golgi transport vesicles, is required for their fusion competence. Lian JP, et al. Cell, 1993 May 21. PMID 8500167

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle fusion with Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ER to Golgi transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bos1p
    NP_013179.1
    • v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      285736..286559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181965.1 → NP_013179.1  TPA: Bos1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013179.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY78, P25385
      UniProtKB/TrEMBL
      A7A0Y2, C8ZD49, G2WIR9
      Conserved Domains (1) summary
      cd15863
      Location:152 → 217
      SNARE_GS27; SNARE motif of GS27
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25385.1

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