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    CAT2 carnitine O-acetyltransferase CAT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854965, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CAT2
    Official Full Name
    carnitine O-acetyltransferase CAT2
    Primary source
    SGD:S000004506
    Locus tag
    YML042W
    See related
    AllianceGenome:SGD:S000004506; FungiDB:YML042W; VEuPathDB:YML042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCAT
    Summary
    Enables carnitine O-acetyltransferase activity. Involved in carnitine metabolic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in Alzheimer's disease; congenital myasthenic syndrome 6; and neurodegeneration with brain iron accumulation. Orthologous to several human genes including CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CAT2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (192788..194800)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Rrn11p Neighboring gene Vps71p Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parallel changes in catabolite repression of haem biosynthesis and cytochromes in repression-resistant mutants of Saccharomyces cerevisiae. Borralho LM, et al. J Gen Microbiol, 1989 May. PMID 2695599
    2. Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae. Cordente AG, et al. FEMS Microbiol Lett, 2007 Feb. PMID 17156120
    3. Genetics of carbon catabolite repression in Saccharomycess cerevisiae: genes involved in the derepression process. Zimmermann FK, et al. Mol Gen Genet, 1977 Feb 28. PMID 194140
    4. Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. Elgersma Y, et al. EMBO J, 1995 Jul 17. PMID 7628448, Free PMC Article
    5. Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling. Violante S, et al. Biochim Biophys Acta, 2010 Sep. PMID 20538056

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. that carnitine protects cells from oxidative and organic acid stress, while CAT2 contributes to the response to oxidative stress.
      Title: Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnitine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carnitine O-acetyltransferase CAT2
    NP_013670.1
    • Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      192788..194800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182400.1 → NP_013670.1  TPA: carnitine O-acetyltransferase CAT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZD3, P32796
      UniProtKB/TrEMBL
      G2WK13, N1P0W9
      Conserved Domains (1) summary
      pfam00755
      Location:74 → 657
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32796.2

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