U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CFT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851895, updated on 22-Aug-2024

    Summary

    Official Symbol
    CFT1
    Primary source
    FungiDB:YDR301W
    Locus tag
    YDR301W
    See related
    SGD:S000002709; AllianceGenome:SGD:S000002709; VEuPathDB:YDR301W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YHH1
    Summary
    Enables RNA binding activity. Involved in mRNA polyadenylation; pre-mRNA cleavage required for polyadenylation; and termination of RNA polymerase II transcription. Located in mitochondrion and nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. Human ortholog(s) of this gene implicated in myopia. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1063352..1067425)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene rRNA-processing protein BFR2 Neighboring gene glutamate 5-kinase Neighboring gene mannose-ethanolamine phosphotransferase GPI11 Neighboring gene Rsc3p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    cleavage/polyadenylation factor CFT1
    NP_010587.1
    • RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1063352..1067425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180609.1NP_010587.1  TPA: cleavage/polyadenylation factor CFT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010587.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VST0, Q06632
      UniProtKB/TrEMBL
      B5VGI0, C7GQV1, N1P736
      Conserved Domains (1) summary
      COG5161
      Location:11353
      SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]