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    COQ1 trans-hexaprenyltranstransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852288, updated on 26-Jun-2024

    Summary

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    Gene symbol
    COQ1
    Gene description
    trans-hexaprenyltranstransferase
    Primary source
    FungiDB:YBR003W
    Locus tag
    YBR003W
    See related
    SGD:S000000207; AllianceGenome:SGD:S000000207; VEuPathDB:YBR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables trans-hexaprenyltranstransferase activity. Involved in ubiquinone biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Orthologous to human PDSS1 (decaprenyl diphosphate synthase subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COQ1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (242809..244230)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene alpha,alpha-trehalase NTH2 Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene GPI-anchor transamidase GPI18 Neighboring gene Rcr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa. Ohara K, et al. J Exp Bot, 2010 Jun. PMID 20421194, Free PMC Article
    2. Biological significance of the side chain length of ubiquinone in Saccharomyces cerevisiae. Okada K, et al. FEBS Lett, 1998 Jul 17. PMID 9708911
    3. Polyprenyl diphosphate synthase essentially defines the length of the side chain of ubiquinone. Okada K, et al. Biochim Biophys Acta, 1996 Aug 16. PMID 8765142
    4. Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase. Ashby MN, et al. J Biol Chem, 1990 Aug 5. PMID 2198286
    5. Overproduction of isoprenoids by Saccharomyces cerevisiae in a synthetic grape juice medium in the absence of plant genes. Camesasca L, et al. Int J Food Microbiol, 2018 Oct 3. PMID 29902782

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The product distribution in the strains indicated that the energy barrier could be the reason that different metal ion-assisted electrophilic attacks initiated carbocation formation.
      Title: ERG9 and COQ1 disruption reveals isoprenoids biosynthesis is closely related to mitochondrial function in Saccharomyces cerevisiae.
    2. Coq1 is functional when expressed alone in E. coli and in budding yeast, but is only functional as a partner with Dps1 in fission yeast.
      Title: Heteromer formation of a long-chain prenyl diphosphate synthase from fission yeast Dps1 and budding yeast Coq1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables heptaprenyl diphosphate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trans-hexaprenyltranstransferase
    NP_009557.1
    • Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      242809..244230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178351.1 → NP_009557.1  TPA: trans-hexaprenyltranstransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ04, P18900
      UniProtKB/TrEMBL
      A0A8H4BT98, A6ZKV0, B3LND7, C7GM46, C8Z3Z9, G2W911
      Conserved Domains (1) summary
      cl00210
      Location:48 → 471
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18900.1

    Gene LinkOut

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