COX13 cytochrome c oxidase subunit VIa [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: COX13
Gene description: cytochrome c oxidase subunit VIa
Primary source: FungiDB:YGL191W
Locus tag: YGL191W
See related: SGD:S000003159; AllianceGenome:SGD:S000003159
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables enzyme regulator activity. Contributes to cytochrome-c oxidase activity. Involved in aerobic respiration and mitochondrial respirasome assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and cytochrome-c oxidase deficiency disease. Orthologous to human COX6A1 (cytochrome c oxidase subunit 6A1) and COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respirasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial respiratory chain complex IV	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_011324.1

Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes