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    COX5A cytochrome c oxidase subunit Va [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855675, updated on 28-Oct-2024

    Summary

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    Official Symbol
    COX5A
    Official Full Name
    cytochrome c oxidase subunit Va
    Primary source
    SGD:S000004997
    Locus tag
    YNL052W
    See related
    AllianceGenome:SGD:S000004997; FungiDB:YNL052W; VEuPathDB:YNL052W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See COX5A in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (531725..532186)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Vac7p Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene Golgi transport complex subunit COG5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial membrane biogenesis: characterization and use of pet mutants to clone the nuclear gene coding for subunit V of yeast cytochrome c oxidase. McEwen JE, et al. J Cell Biochem, 1984. PMID 6330135
    2. The isoforms of yeast cytochrome c oxidase subunit V alter the in vivo kinetic properties of the holoenzyme. Waterland RA, et al. J Biol Chem, 1991 Mar 5. PMID 1847916
    3. An unusual mitochondrial import pathway for the precursor to yeast cytochrome c oxidase subunit Va. Miller BR, et al. J Cell Biol, 1991 Mar. PMID 1847927, Free PMC Article
    4. A yeast mitochondrial leader peptide functions in vivo as a dual targeting signal for both chloroplasts and mitochondria. Huang J, et al. Plant Cell, 1990 Dec. PMID 1967076, Free PMC Article
    5. Cloning and characterization of the yeast nuclear gene for subunit 5 of cytochrome oxidase. Koerner TJ, et al. J Biol Chem, 1985 Aug 15. PMID 2991248

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of isoenzymes cox5a and cox5b indicate that the elevated activity of cox5b in the rox1 mutant is not caused by exchange of isoforms.
      Title: Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase.
    2. COX5a is switched off and COX5b is switched on when the O2 concentration drops below a threshold of 0.5 microM O2.
      Title: Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit Va
    NP_014346.1
    • Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      531725..532186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182891.1 → NP_014346.1  TPA: cytochrome c oxidase subunit Va [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1C7, P00424
      UniProtKB/TrEMBL
      A6ZS26, B3LNR3, C7GLU9, C8ZGH6, G2WM51, N1P4I7
      Conserved Domains (1) summary
      pfam02936
      Location:34 → 152
      COX4; Cytochrome c oxidase subunit IV
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00424.1

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