U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CPA2 carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853573, updated on 28-Oct-2024

    Summary

    Official Symbol
    CPA2
    Official Full Name
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
    Primary source
    SGD:S000003870
    Locus tag
    YJR109C
    See related
    AllianceGenome:SGD:S000003870; FungiDB:YJR109C; VEuPathDB:YJR109C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. Involved in L-arginine biosynthetic process. Part of carbamoyl-phosphate synthase complex. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CPA2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (629585..632941, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Abm1p Neighboring gene phosphatidylinositol-3-phosphatase YMR1 Neighboring gene Pxp2p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of carbamoyl-phosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2
    NP_012643.3
    • Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      629585..632941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181767.3NP_012643.3  TPA: carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWS8, P03965
      UniProtKB/TrEMBL
      A6ZQ65, B3LQJ3, B5VLQ3, C7GMA0, C8ZBQ7, G2WHB2, N1P185
      Conserved Domains (1) summary
      TIGR01369
      Location:231084
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit