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    DDR48 DNA damage-responsive protein 48 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855210, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DDR48
    Official Full Name
    DNA damage-responsive protein 48
    Primary source
    SGD:S000004784
    Locus tag
    YMR173W
    See related
    AllianceGenome:SGD:S000004784; FungiDB:YMR173W; VEuPathDB:YMR173W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity and GTPase activity. Involved in DNA repair. Located in cytosol. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See DDR48 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (608689..609981)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ear1p Neighboring gene Hot1p Neighboring gene Pai3p Neighboring gene Sip18p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the DNA damage-inducible gene DDR48 and evidence for its role in mutagenesis in Saccharomyces cerevisiae. Treger JM, et al. Mol Cell Biol, 1990 Jun. PMID 2111448, Free PMC Article
    2. Purification and characterization of Saccharomyces cerevisiae DNA damage-responsive protein 48 (DDRP 48). Sheng S, et al. J Biol Chem, 1993 Mar 5. PMID 8444852
    3. DNA damage and heat shock dually regulate genes in Saccharomyces cerevisiae. McClanahan T, et al. Mol Cell Biol, 1986 Jan. PMID 3023840, Free PMC Article
    4. Transcriptional regulation of DNA damage responsive (DDR) genes in different rad mutant strains of Saccharomyces cerevisiae. Maga JA, et al. Mol Gen Genet, 1986 Nov. PMID 3100912
    5. Yeast adapts to a changing stressful environment by evolving cross-protection and anticipatory gene regulation. Dhar R, et al. Mol Biol Evol, 2013 Mar. PMID 23125229

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    DNA damage-responsive protein 48
    NP_013897.1
    • DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      608689..609981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182678.1 → NP_013897.1  TPA: DNA damage-responsive protein 48 [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZZ5, P18899
      UniProtKB/TrEMBL
      A6ZMN2
      Conserved Domains (2) summary
      PTZ00110
      Location:327 → 393
      PTZ00110; helicase; Provisional
      NF033849
      Location:80 → 357
      ser_rich_anae_1; serine-rich protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18899.4

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